{"id":"W4252867417","doi":"10.1200/jco.20.03570","title":"Therapy for Stage IV Non–Small-Cell Lung Cancer With Driver Alterations: ASCO and OH (CCO) Joint Guideline Update","year":2021,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":301,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre; Juravinski Cancer Centre; Kingston General Hospital; University Health Network; Queen's University","funders":"","keywords":"Medicine; Guideline; Lung cancer; Oncology; Internal medicine; Targeted therapy; T790M; Osimertinib; Stage (stratigraphy); Cancer; Clinical endpoint; Clinical trial; Erlotinib; Epidermal growth factor receptor; Gefitinib; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.008337604,0.001398066,0.003462724,0.003669586,0.0008981391,0.002355557,0.003838165,0.004566391,0.004444753],"category_scores_gemma":[0.02105607,0.0006689863,0.006134602,0.003643869,0.000657944,0.001626232,0.002051621,0.004463574,0.003040651],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003991749,"about_ca_system_score_gemma":0.01407105,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02438121,"about_ca_topic_score_gemma":0.04521447,"domain_scores_codex":[0.9917119,0.002757058,0.002315911,0.000387286,0.002354219,0.000473571],"domain_scores_gemma":[0.9842659,0.003596329,0.002521195,0.0003590344,0.008507093,0.0007504867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001659776,0.0001136338,0.001376981,0.03719794,0.001182621,0.0002181029,0.0002146241,0.001122107,0.000757008,0.002995024,0.6764058,0.2782502],"study_design_scores_gemma":[0.0005380879,0.0001440373,0.003529827,0.08483252,0.002729944,0.0005158191,0.0001276352,0.0005988344,0.0004198461,0.004029133,0.9024492,0.00008525901],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"review","genre_gemma":"other","genre_scores_codex":[0.00360116,0.7170788,0.01274356,0.1731736,0.01858571,0.005370835,0.02067341,0.0007694712,0.04800336],"genre_scores_gemma":[0.0243238,0.7113166,0.07987592,0.1142929,0.008079384,0.008383619,0.03230352,0.0004137291,0.02101047],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.02438121,"threshold_uncertainty_score":0.0484786,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08343939901888191,"score_gpt":0.49462702697377,"score_spread":0.4111876279548881,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}