{"id":"W4252935767","doi":"10.26434/chemrxiv.13728112","title":"Enzymatic β-Oxidation of the Cholesterol Side Chain in Mycobacterium Tuberculosis Bifurcates Stereospecifically at Hydration of 3-Oxo-Cholest-4,22- Dien-24-Oyl-CoA","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Steroid Chemistry and Biochemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Brookhaven National Laboratory; Office of Science; National Institutes of Health; National Institute of Advanced Industrial Science and Technology; University of British Columbia; McGill University; U.S. Department of Energy","keywords":"Chemistry; Stereochemistry; Enzyme; NAD+ kinase; Dehydrogenase; Stereospecificity; Biochemistry; Cofactor; Catalysis","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0000911894,0.0002358147,0.0001480783,0.000184245,0.0001389619,0.0002749119,0.0001342813,0.0002230705,0.0003466151],"category_scores_gemma":[0.0001529797,0.0001507477,0.0002447442,0.0001959251,0.0002484167,0.000130111,0.0002464978,0.000374162,0.0004082797],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003946715,"about_ca_system_score_gemma":0.000312849,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002819268,"about_ca_topic_score_gemma":0.002668557,"domain_scores_codex":[0.9998928,0.00001140206,0.00000925168,0.00002669391,0.00003329514,0.00002648073],"domain_scores_gemma":[0.9999102,0.00001064341,0.00003508455,0.00001398979,0.00001178167,0.0000183015],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005467555,0.0000144525,0.001349768,0.0000149201,0.000002230361,0.00005572947,0.00002572817,0.00004125128,0.9973111,0.00005745861,0.00002343448,0.001049213],"study_design_scores_gemma":[0.00001163679,0.0001545877,0.02144344,0.000005812399,0.00001209019,0.0003913569,0.0001363571,0.000640343,0.9751402,0.00009306625,0.001964269,0.000006921556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.997401,0.0003267863,0.001264569,0.0001045938,0.00001612214,0.00001664638,0.0002804631,0.00004454641,0.000545272],"genre_scores_gemma":[0.9954386,0.0002268884,0.002018054,0.00006420779,0.000006174169,0.00001667202,0.0007267502,0.00001693552,0.001485651],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002819268,"threshold_uncertainty_score":0.005605638,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01101071085056996,"score_gpt":0.2240288501445435,"score_spread":0.2130181392939735,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}