{"id":"W4252946082","doi":"10.1042/bj3530483","title":"mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2","year":2001,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"","keywords":"SIGLEC; Immunoreceptor tyrosine-based activation motif; Biology; Immunoglobulin superfamily; Protein tyrosine phosphatase; Immunoglobulin domain; SH2 domain; Proto-oncogene tyrosine-protein kinase Src; Molecular biology; Sialic acid; Biochemistry; Tyrosine; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00004217512,0.0003002781,0.00009914885,0.0003358074,0.0001004783,0.0002333556,0.0001561927,0.0002119741,0.0008070244],"category_scores_gemma":[0.0000560032,0.00006677394,0.0001359358,0.0002235455,0.0001393977,0.0001835319,0.0001831286,0.0001935718,0.0002936921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002421874,"about_ca_system_score_gemma":0.0001213211,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002471535,"about_ca_topic_score_gemma":0.0005135699,"domain_scores_codex":[0.9999539,0.000004699809,0.000003499577,0.00001170619,0.00001576651,0.00001050956],"domain_scores_gemma":[0.9999634,0.000002948384,0.00001193703,0.000002426875,0.000004764624,0.00001453794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00004690482,0.00001805838,0.001258001,0.00003802183,0.000005940235,0.0001659149,0.00001038356,0.00007370163,0.9911399,0.0002971337,0.0002126908,0.006733422],"study_design_scores_gemma":[0.00002289531,0.000290758,0.02774096,0.00001584766,0.00004181582,0.003343662,0.00004963071,0.00221563,0.9335486,0.0002512639,0.03246314,0.00001584472],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9856414,0.00330184,0.006742965,0.0001377116,0.00003374563,0.00004031892,0.0006951078,0.0001977852,0.003209126],"genre_scores_gemma":[0.9842591,0.002232925,0.005458216,0.0001123866,0.00002055773,0.0000271918,0.002040545,0.00001651148,0.005832648],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008070244,"threshold_uncertainty_score":0.002699733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02496573117547602,"score_gpt":0.2744526328681052,"score_spread":0.2494869016926292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}