{"id":"W4252946082","doi":"10.1042/bj3530483","title":"mSiglec-E, a novel mouse CD33-related siglec (sialic acid-binding immunoglobulin-like lectin) that recruits Src homology 2 (SH2)-domain-containing protein tyrosine phosphatases SHP-1 and SHP-2","year":2001,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":39,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; Biotechnology Research Institute","funders":"","keywords":"SIGLEC; Immunoreceptor tyrosine-based activation motif; Biology; Immunoglobulin superfamily; Protein tyrosine phosphatase; Immunoglobulin domain; SH2 domain; Proto-oncogene tyrosine-protein kinase Src; Molecular biology; Sialic acid; Biochemistry; Tyrosine; Signal transduction; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006890111,0.0004543162,0.0004397977,0.0002298501,0.000508729,0.0002516272,0.0004910755,0.000611563,0.0002540236],"category_scores_gemma":[0.0004745112,0.0004210142,0.0002174998,0.0004174223,0.0003172912,0.00003529797,0.0003592031,0.0008476759,0.00003574948],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001276199,"about_ca_system_score_gemma":0.0002727969,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005444176,"about_ca_topic_score_gemma":0.00001767276,"domain_scores_codex":[0.9969591,0.000185126,0.0006596731,0.0007251308,0.0004939764,0.0009769815],"domain_scores_gemma":[0.9984236,0.00004152824,0.0003291819,0.000432708,0.0002674937,0.0005055033],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001164435,0.0002085647,0.001171243,0.0000213384,0.0001687581,0.0001164577,0.00008118503,0.000004373157,0.9925125,0.00006969117,0.001960744,0.002520725],"study_design_scores_gemma":[0.003812217,0.0008339718,0.0004388809,0.0001160865,0.00003284395,0.002929612,0.0002236767,0.00004591441,0.9635773,0.0001024945,0.02734686,0.0005401158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892654,0.006846615,0.001864029,0.0007125936,0.0002384087,0.0006398364,0.00004086511,0.00004425018,0.0003479656],"genre_scores_gemma":[0.9934194,0.000930755,0.00239206,0.0003005259,0.0004015721,0.00006347732,0.0002702007,0.00007491008,0.002147102],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02893515,"threshold_uncertainty_score":0.9998242,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02496573117547602,"score_gpt":0.2744526328681052,"score_spread":0.2494869016926292,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}