{"id":"W4253046835","doi":"10.1002/9783527814527.ch17","title":"Engineering of the <scp> <i>Neurospora</i> </scp> Varkud Satellite Ribozyme for Cleavage of Nonnatural Stem‐Loop Substrates","year":2021,"lang":"en","type":"other","venue":"","topic":"RNA and protein synthesis mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"","keywords":"Ribozyme; Hairpin ribozyme; VS ribozyme; Stem-loop; Cleavage (geology); Mammalian CPEB3 ribozyme; Neurospora; Ligase ribozyme; Biology; RNA; Computational biology; Stereochemistry; Chemistry; Genetics; Biophysics; Neurospora crassa; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001705111,0.0003019601,0.0002667666,0.0001708565,0.00007628455,0.0003431948,0.0002363552,0.0002416006,0.0002495576],"category_scores_gemma":[0.0001699102,0.0001472471,0.0003742722,0.0001861343,0.0001797057,0.0001663809,0.0001432209,0.0003503578,0.0002400002],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003666266,"about_ca_system_score_gemma":0.000210219,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000356725,"about_ca_topic_score_gemma":0.0004773785,"domain_scores_codex":[0.9998726,0.00003151292,0.0000219346,0.00001949315,0.00003733785,0.00001717295],"domain_scores_gemma":[0.9999492,0.00001481706,0.00001647455,0.0000053121,0.000007751648,0.000006416011],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005267465,0.000009996936,0.0002408225,0.0003114876,0.00002151092,0.0002629285,0.00003461743,0.001057887,0.9888034,0.001187312,0.00007824495,0.007939032],"study_design_scores_gemma":[0.00001289187,0.0001558907,0.001352341,0.00002690521,0.00004233875,0.0006742296,0.00003774329,0.002162357,0.9845877,0.0003177423,0.01061954,0.00001026867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9170865,0.01745361,0.05266436,0.0002707617,0.000160332,0.0001734563,0.0004282575,0.000255173,0.01150742],"genre_scores_gemma":[0.9580905,0.01154922,0.02697003,0.0001043872,0.00002983893,0.00005809338,0.0005309049,0.00005937367,0.002607726],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0003666266,"threshold_uncertainty_score":0.002660096,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01005507026874112,"score_gpt":0.2083891397695407,"score_spread":0.1983340695007996,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}