{"id":"W4253067350","doi":"10.21203/rs.2.142/v2","title":"RTS,S malaria vaccine pilot studies: addressing the human realities in large-scale clinical trials","year":2019,"lang":"en","type":"preprint","venue":"Research Square","topic":"Malaria Research and Control","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"International Development Research Centre; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Malaria vaccine; Malaria; Scale (ratio); Clinical trial; Medicine; Environmental health; Geography; Plasmodium falciparum; Cartography; Immunology; Internal medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":["metaresearch"],"consensus_categories":["metaresearch"],"category_scores_codex":[0.4651968,0.001068065,0.001521682,0.0008609332,0.00185938,0.005936962,0.001785771,0.002845002,0.007772229],"category_scores_gemma":[0.4342022,0.0007199507,0.000825486,0.001548951,0.005153342,0.004134066,0.003693413,0.003419342,0.001565166],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.003168769,"about_ca_system_score_gemma":0.01875806,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008024525,"about_ca_topic_score_gemma":0.00239155,"domain_scores_codex":[0.5256389,0.4526737,0.008306852,0.001735295,0.009757753,0.001887436],"domain_scores_gemma":[0.4848546,0.4200501,0.02819053,0.03263718,0.02683244,0.007435061],"domain_codex":null,"domain_gemma":"methods","domain_candidate":"methods","domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"qualitative","study_design_scores_codex":[0.05117264,0.01354907,0.03441519,0.02130811,0.003306739,0.002017287,0.01708251,0.009052173,0.008662838,0.1064302,0.05082548,0.6821777],"study_design_scores_gemma":[0.06244268,0.1957701,0.0578279,0.02116291,0.003952607,0.001967898,0.01608243,0.01643187,0.01724395,0.2280164,0.3785525,0.0005487052],"study_design_candidate":"qualitative","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3536206,0.02186551,0.1633741,0.2065385,0.007711488,0.1709966,0.001904248,0.0008534705,0.07313548],"genre_scores_gemma":[0.63629,0.00725523,0.2034565,0.01568625,0.002284892,0.1272289,0.0006169577,0.0001952657,0.006986078],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5348032,"threshold_uncertainty_score":0.6595076,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.5274787901063049,"score_gpt":0.58988443434177,"score_spread":0.06240564423546502,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}