{"id":"W4253141243","doi":"10.2174/13895575113139990058","title":"Structure and Thermodynamics of Drug-RNA Aptamer Interactions","year":2013,"lang":"en","type":"article","venue":"Mini-Reviews in Medicinal Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"","keywords":"Aptamer; RNA; Drug; Computational biology; Chemistry; Thermodynamics; Physics; Biology; Molecular biology; Pharmacology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005283779,0.0006177854,0.0007875046,0.0002726332,0.0004639198,0.0008128842,0.0009728493,0.0007276468,0.00722078],"category_scores_gemma":[0.0006083719,0.0004947911,0.0005531117,0.0002375148,0.0006645655,0.001277716,0.0005930852,0.001012416,0.00224847],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008383073,"about_ca_system_score_gemma":0.0003733706,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003938727,"about_ca_topic_score_gemma":0.0005230537,"domain_scores_codex":[0.9995881,0.00007837009,0.00002460933,0.00009562114,0.0001529402,0.00006045567],"domain_scores_gemma":[0.9998052,0.0001152143,0.00003426713,0.000009819018,0.00002480723,0.00001070697],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0002610896,0.0001781154,0.001217853,0.00971552,0.0002560861,0.0008419252,0.0004413827,0.02102878,0.759757,0.1015501,0.007629913,0.09712232],"study_design_scores_gemma":[0.00006713355,0.001369713,0.007261119,0.0004975717,0.0002140611,0.002724779,0.000317254,0.035624,0.6918889,0.06496202,0.194844,0.0002295248],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.2820294,0.5434317,0.07842629,0.00282518,0.002261032,0.0003090007,0.001333154,0.0005259588,0.08885833],"genre_scores_gemma":[0.7761321,0.1855126,0.01700689,0.001285927,0.000786183,0.0004703285,0.001347989,0.000209369,0.01724862],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.00722078,"threshold_uncertainty_score":0.02415591,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006631253009046487,"score_gpt":0.2521163074355565,"score_spread":0.24548505442651,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}