{"id":"W4253190746","doi":"10.1002/chin.200327257","title":"A Highly Selective Cell Permeable Peptide Inhibitor of Proprotein Convertase 1: Design, Synthesis and Biological Evaluation in Cellular PC1 Mediated Proteolysis","year":2003,"lang":"en","type":"article","venue":"ChemInform","topic":"Enzyme Structure and Function","field":"Materials Science","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Ottawa","funders":"","keywords":"Chemistry; Proprotein convertase; Proteolysis; Peptide; Cell; Proprotein Convertases; Biochemistry; Combinatorial chemistry; Computational biology; Enzyme; Lipoprotein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001059285,0.00014778,0.0002399061,0.00008824391,0.00005219013,0.00001997924,0.00007214123,0.0001578491,0.0004313771],"category_scores_gemma":[0.0009870847,0.0001119642,0.00003201367,0.0002238461,0.0001032538,0.0001810096,0.00002042263,0.00009196256,0.00001961481],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001016572,"about_ca_system_score_gemma":0.0001389776,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00006479595,"about_ca_topic_score_gemma":0.000009202848,"domain_scores_codex":[0.9989302,0.0000221111,0.0003179626,0.0002552685,0.0002575836,0.0002169271],"domain_scores_gemma":[0.9993211,0.0001401519,0.0001687142,0.0001438798,0.0001674964,0.0000586408],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000086724,0.00004370096,0.0003539833,0.00007313189,0.000004559341,0.000001445542,0.0005406172,0.00001047509,0.9975295,0.00002079433,0.0001637558,0.00117129],"study_design_scores_gemma":[0.0005228404,0.0001326967,0.0003268142,0.00003426103,0.00002827056,0.000002906922,0.000241973,0.000355938,0.9978355,0.0002715888,0.0001061009,0.0001411802],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9888313,0.0001506756,0.00007139891,0.00001225771,0.00005412161,0.001041485,0.000009838919,0.00002654332,0.009802309],"genre_scores_gemma":[0.9983507,0.00001082071,0.001065634,0.00001562964,0.00002152259,0.0003467207,0.00001374563,0.000007930494,0.0001673004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.009635009,"threshold_uncertainty_score":0.4723277,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01889373777140058,"score_gpt":0.2126555825315736,"score_spread":0.193761844760173,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}