{"id":"W4253228422","doi":"10.1126/stke.2000.62.tw7","title":"Transcription-Independent p53 Apoptosis Requires Caspase-8","year":2000,"lang":"en","type":"article","venue":"Science s STKE","topic":"Cancer-related Molecular Pathways","field":"Medicine","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Apoptosis; FADD; Cell biology; NLRP1; Inhibitor of apoptosis domain; Transcription factor; Caspase 8; Biology; Caspase; Caspase 10; Intrinsic apoptosis; Transcription (linguistics); Caspase 3; Programmed cell death; Molecular biology; Gene; Biochemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0004201143,0.0001448714,0.0001854019,0.0001976587,0.0002627886,0.00005748614,0.0002551135,0.00007891854,0.00289488],"category_scores_gemma":[0.00005982997,0.0001296032,0.000110555,0.0009241517,0.0005297499,0.0002498149,0.00001992297,0.0002211974,0.0005468625],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002519698,"about_ca_system_score_gemma":0.0005133403,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002170544,"about_ca_topic_score_gemma":0.0000467579,"domain_scores_codex":[0.997811,0.00001998195,0.0002275424,0.0005100644,0.0009326921,0.000498675],"domain_scores_gemma":[0.9990314,0.00001062866,0.00003529582,0.0005045616,0.0001082563,0.0003098793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009869121,0.0001221532,0.0001850422,0.00002036066,0.00001727714,0.00004809275,0.0007893173,0.0001314876,0.9301193,0.0005528075,0.001220222,0.0666953],"study_design_scores_gemma":[0.003118904,0.0008767529,0.01389218,0.0002791088,0.0001938771,0.000460844,0.0005098412,0.00129441,0.9188148,0.0006383773,0.05931674,0.0006041485],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9447213,0.0003177282,0.0002874157,0.001566746,0.0004939964,0.0003510845,0.00001174242,0.0001389288,0.05211108],"genre_scores_gemma":[0.9946847,0.0001152835,0.0006302806,0.0006924376,0.0001139174,0.00002209305,0.00000571666,0.00001763462,0.003717956],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06609114,"threshold_uncertainty_score":0.9980166,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01647296587621284,"score_gpt":0.2694842480107575,"score_spread":0.2530112821345447,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}