{"id":"W4253309485","doi":"10.1002/ange.201710144","title":"Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy","year":2017,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institutes of Health","keywords":"RNA interference; Nanomedicine; Endosome; Cancer therapy; Gene silencing; Chemistry; Cancer research; Cancer cell; Gene knockdown; Cell biology; Cancer; Nanotechnology; Biophysics; Nanoparticle; Biology; Cell; Materials science; Biochemistry; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003512049,0.0001936404,0.0002590427,0.00003610321,0.0002974968,0.0001310779,0.0004086682,0.00007763166,0.0006872239],"category_scores_gemma":[0.0002821936,0.0001735034,0.00007747837,0.0000480257,0.00007958085,0.0002413632,0.00008534788,0.00008275211,0.00007181805],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000121128,"about_ca_system_score_gemma":0.0001078329,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001522474,"about_ca_topic_score_gemma":0.00001027175,"domain_scores_codex":[0.9987072,0.000009377635,0.0002294385,0.0003722722,0.0002776591,0.0004040761],"domain_scores_gemma":[0.9989253,0.0001244521,0.0001270442,0.0004391432,0.0001840667,0.000199978],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002510375,0.00007185295,0.000697137,0.00002693182,0.00002015091,0.000003689356,0.0001105425,0.0001499582,0.9849727,0.0001436277,0.01305818,0.0004941915],"study_design_scores_gemma":[0.002866418,0.00009544141,0.0007137461,0.00005486135,0.00001422594,0.00000129318,0.00001038021,0.0001773752,0.9321221,0.00008782696,0.0636447,0.0002116125],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9895385,0.0006856801,0.0005315954,0.001524327,0.006711104,0.0005128529,0.0001838391,0.00009791681,0.0002142219],"genre_scores_gemma":[0.9961115,0.0000471829,0.001157234,0.0003929198,0.00156875,0.000335697,0.0000278072,0.00003372767,0.0003251974],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05285058,"threshold_uncertainty_score":0.752462,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02485064092666097,"score_gpt":0.2804949397451577,"score_spread":0.2556442988184967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}