{"id":"W4253309485","doi":"10.1002/ange.201710144","title":"Engineering Multifunctional RNAi Nanomedicine To Concurrently Target Cancer Hallmarks for Combinatorial Therapy","year":2017,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Nanoparticle-Based Drug Delivery","field":"Materials Science","cited_by":36,"is_retracted":false,"has_abstract":true,"ca_institutions":"BC Cancer Agency","funders":"National Institutes of Health","keywords":"RNA interference; Nanomedicine; Endosome; Cancer therapy; Gene silencing; Chemistry; Cancer research; Cancer cell; Gene knockdown; Cell biology; Cancer; Nanotechnology; Biophysics; Nanoparticle; Biology; Cell; Materials science; Biochemistry; RNA; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001852581,0.0004039551,0.0001984202,0.0002720208,0.00012642,0.0003144796,0.0002466668,0.0003215441,0.0009909614],"category_scores_gemma":[0.0001355716,0.0001627743,0.0002192965,0.0001286539,0.0002094263,0.0003022277,0.0002974771,0.0003416926,0.0004462741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004505249,"about_ca_system_score_gemma":0.0002472793,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002754508,"about_ca_topic_score_gemma":0.0005562572,"domain_scores_codex":[0.9999241,0.00001095573,0.000007329282,0.00002256041,0.00001941723,0.00001569516],"domain_scores_gemma":[0.99994,0.00001014217,0.00002141453,0.000006025091,0.00001077166,0.00001158316],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002541013,0.00002887071,0.00006168355,0.00005077446,0.000006186804,0.00004214564,0.00001172911,0.0007106456,0.9925707,0.00107544,0.0001794538,0.005236987],"study_design_scores_gemma":[0.00002171801,0.0001668671,0.0002130789,0.000004424973,0.00001484535,0.0001107712,0.000005414604,0.006555188,0.9866101,0.0001808924,0.006109489,0.000007252994],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7702963,0.004612255,0.2051067,0.000609104,0.0001944879,0.000530903,0.0004009259,0.001062557,0.01718688],"genre_scores_gemma":[0.9353049,0.0009582435,0.05939462,0.0001485021,0.00002195854,0.0002042578,0.00011055,0.00006161921,0.003795323],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009909614,"threshold_uncertainty_score":0.003315091,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02485064092666097,"score_gpt":0.2804949397451577,"score_spread":0.2556442988184967,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}