{"id":"W4253316994","doi":"10.3410/f.1157206.617324","title":"Faculty Opinions recommendation of Modulating serine palmitoyl transferase (SPT) expression and activity unveils a crucial role in lipid-induced insulin resistance in rat skeletal muscle cells.","year":2009,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"Muscle metabolism and nutrition","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Insulin resistance; Skeletal muscle; Serine; Chemistry; Transferase; Cell biology; Insulin; Endocrinology; Biology; Biochemistry; Enzyme","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001074887,0.001870333,0.001399849,0.002062479,0.0004939156,0.001623847,0.002110859,0.001943288,0.01929569],"category_scores_gemma":[0.005280465,0.0004512973,0.001477,0.003042498,0.0003077513,0.000715334,0.0009915909,0.001323196,0.01695241],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001143635,"about_ca_system_score_gemma":0.002049104,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02280255,"about_ca_topic_score_gemma":0.05345379,"domain_scores_codex":[0.9990171,0.0001682665,0.00009777965,0.0003613143,0.0002479783,0.0001075665],"domain_scores_gemma":[0.9982402,0.000687636,0.0002406593,0.0003490126,0.0003113486,0.0001711951],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0005900732,0.00008552568,0.00766504,0.002360477,0.0003552877,0.00009019874,0.00002801121,0.001106891,0.001203548,0.0005381801,0.9756049,0.01037183],"study_design_scores_gemma":[0.00122045,0.00010876,0.04655908,0.0004689743,0.0005882803,0.000261526,0.00007714961,0.002831528,0.004329751,0.001520325,0.9419526,0.00008150784],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.001211249,0.0002797865,0.0001249486,0.0001330547,0.00003270787,0.00001092036,0.9971218,0.0002843174,0.0008012422],"genre_scores_gemma":[0.002310564,0.0001533277,0.0005003997,0.00007645084,0.000007842015,0.00004550926,0.9960873,0.00004104872,0.0007775952],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.02280255,"threshold_uncertainty_score":0.06455052,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0156955282777307,"score_gpt":0.307842662779914,"score_spread":0.2921471345021833,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}