{"id":"W4253372269","doi":"10.1002/ajmg.c.30138","title":"Noonan syndrome","year":2007,"lang":"en","type":"review","venue":"American Journal of Medical Genetics Part C Seminars in Medical Genetics","topic":"Protein Tyrosine Phosphatases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"Children's Hospital of Eastern Ontario","funders":"","keywords":"Noonan syndrome; Medicine; Internal medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":["research_integrity"],"category_scores_codex":[0.005604994,0.001002513,0.003329116,0.0005629519,0.00007255677,0.00004933805,0.003783279,0.001768578,0.0004769419],"category_scores_gemma":[0.003989972,0.0008510849,0.0009585606,0.001126012,0.002219444,0.000005021216,0.001111296,0.002553303,0.00004134234],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001683186,"about_ca_system_score_gemma":0.004710032,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001263002,"about_ca_topic_score_gemma":0.00002676989,"domain_scores_codex":[0.9880019,0.0008471997,0.003666188,0.0009158254,0.005296505,0.001272361],"domain_scores_gemma":[0.9935058,0.000543032,0.002111569,0.001161289,0.0002974531,0.002380865],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0000471281,0.0003024431,0.0001157875,0.0009949009,0.0003064906,0.003352193,0.00002192438,0.000007123456,0.000003271003,0.00001867312,0.0072187,0.9876114],"study_design_scores_gemma":[0.0007800036,0.002789994,0.00002399853,0.01716157,0.0004327706,0.01041848,0.00006075726,0.00002151655,0.0002102856,0.00003420814,0.967261,0.0008053986],"study_design_candidate":"design_other","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001438512,0.9946391,0.00150138,0.0002858569,0.001485796,0.000480676,0.0000716875,0.00001091631,0.0000860658],"genre_scores_gemma":[0.0003839123,0.99093,0.005318321,0.001086518,0.001749636,0.00003472136,0.0002062089,0.0002009061,0.00008982444],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.986806,"threshold_uncertainty_score":0.9997479,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0261103276916335,"score_gpt":0.3678312311426746,"score_spread":0.3417209034510411,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}