{"id":"W4253473443","doi":"10.1200/jco.2019.37.15_suppl.tps5100","title":"PROTEUS: A randomized, double-blind, placebo (PBO)-controlled, phase 3 trial of apalutamide (APA) plus androgen deprivation therapy (ADT) versus PBO plus ADT prior to radical prostatectomy (RP) in patients with localized high-risk or locally advanced prostate cancer (PC).","year":2019,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Prostate Cancer Treatment and Research","field":"Medicine","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Medicine; Androgen deprivation therapy; Prostatectomy; Prostate cancer; Urology; Antiandrogen; Internal medicine; Placebo; Randomization; Oncology; Randomized controlled trial; Cancer; Pathology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001359403,0.002160951,0.00286583,0.0006342929,0.0006426454,0.001435873,0.00120487,0.002039201,0.008570935],"category_scores_gemma":[0.0015889,0.0008007258,0.001893657,0.0004748942,0.001590983,0.00121606,0.0005432456,0.003583802,0.001561806],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007984225,"about_ca_system_score_gemma":0.001868673,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001069671,"about_ca_topic_score_gemma":0.003059399,"domain_scores_codex":[0.9994991,0.0002510934,0.0000242244,0.0001012798,0.00004154303,0.00008279327],"domain_scores_gemma":[0.9992855,0.0001499147,0.0001898875,0.00004897654,0.00005104843,0.0002745864],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.9800724,0.00706591,0.0001899026,0.0006770822,0.0004550469,0.00002343291,0.00003506888,0.0001614309,0.00249694,0.0001279443,0.0007074224,0.007987319],"study_design_scores_gemma":[0.9659932,0.03256621,0.0004068843,0.00002673976,0.0001371143,0.00001859205,0.00001290261,0.0001652883,0.000177007,0.0001306444,0.0003568691,0.000008583591],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9694421,0.006405384,0.001346011,0.001551227,0.001537543,0.01291109,0.002294126,0.0005040819,0.004008425],"genre_scores_gemma":[0.9655342,0.003733184,0.003523353,0.002315149,0.0006346086,0.01671718,0.001544898,0.00006762965,0.005929836],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.008570935,"threshold_uncertainty_score":0.02867264,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06609354285625957,"score_gpt":0.4441969526438792,"score_spread":0.3781034097876196,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}