{"id":"W4253522419","doi":"10.1007/s100590000007","title":"Characterization of Mutant HIV-1 Integrase Carrying Amino Acid Changes in the Catalytic Domain","year":2000,"lang":"en","type":"article","venue":"Molecules and Cells","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":false,"ca_institutions":"Armand Frappier Museum; Université de Montréal","funders":"","keywords":"Mutant; Mutagenesis; Integrase; Enzyme; Amino acid; Chemistry; Isoleucine; Biochemistry; Biology; Leucine; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001517829,0.0004176717,0.0002454476,0.0002049964,0.000180187,0.0004079035,0.0003208236,0.0004647942,0.0007739368],"category_scores_gemma":[0.0003619289,0.0001485058,0.0002686255,0.0001982556,0.0002565753,0.000212022,0.0001101935,0.0006429311,0.0003526843],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002966269,"about_ca_system_score_gemma":0.0001969618,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001175256,"about_ca_topic_score_gemma":0.0006769964,"domain_scores_codex":[0.9998753,0.00002037168,0.00001756197,0.00002241652,0.00004224147,0.00002215465],"domain_scores_gemma":[0.9997689,0.00006784777,0.00005487912,0.00003532062,0.00003384621,0.00003923272],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007953381,0.00004145617,0.0001694782,0.00001098785,0.000005772943,0.0001110282,0.0000156125,0.0000821049,0.9989686,0.0001101311,0.0000152391,0.000390188],"study_design_scores_gemma":[0.00002286251,0.0001826364,0.002915864,0.000005007267,0.00002398563,0.001148123,0.00003687379,0.001231549,0.9931611,0.00005642435,0.001208264,0.000007274256],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996987,0.0002357698,0.001726878,0.00009389246,0.00002501251,0.00001814789,0.0003393662,0.00002286704,0.0005510935],"genre_scores_gemma":[0.9952473,0.0001800018,0.001888352,0.0000512386,0.000007489009,0.00001257982,0.00127774,0.00003182767,0.001303503],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001175256,"threshold_uncertainty_score":0.002589047,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.006894816889893893,"score_gpt":0.2101359764204704,"score_spread":0.2032411595305765,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}