{"id":"W4253535444","doi":"10.1210/en.142.1.276","title":"Identification of Insulin Domains Important for Binding to and Degradation by Endosomal Acidic Insulinase","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Cellular transport and secretion","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Institut National de la Santé et de la Recherche Médicale; Shriners Hospitals for Children; McGill University","keywords":"Proteolysis; Endosome; Endopeptidase; Insulin; Biochemistry; Insulin-degrading enzyme; Cleavage (geology); Peptide; Peptide bond; Chemistry; Amino acid; Insulin receptor; Mutant; Biology; Enzyme; Receptor; Endocrinology; Insulin resistance","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001566423,0.0002177225,0.0002027125,0.0001281075,0.00007724622,0.0003427318,0.0001079053,0.0002303042,0.0004763792],"category_scores_gemma":[0.0002473199,0.0001878893,0.0002132473,0.0001187171,0.0001752222,0.000188434,0.00009645322,0.0003261341,0.00033108],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003961432,"about_ca_system_score_gemma":0.0001284758,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0006627514,"about_ca_topic_score_gemma":0.0005403751,"domain_scores_codex":[0.9998918,0.00002056062,0.000009455932,0.00002371072,0.00002485122,0.00002973139],"domain_scores_gemma":[0.9998265,0.00003872404,0.00005743578,0.0000160198,0.00001855591,0.00004270195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001846384,0.00001120706,0.0008381201,0.00001354835,0.00000280132,0.00004437098,0.00001065755,0.00005469609,0.9976925,0.00004982378,0.00001187345,0.001085838],"study_design_scores_gemma":[0.00002063279,0.0002341515,0.03586513,0.000005990941,0.00001732916,0.0009003041,0.00004213451,0.0019799,0.9593666,0.00008088326,0.001478107,0.000008871059],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963226,0.001010437,0.002145431,0.00002271266,0.000004015512,0.000007115667,0.0001159785,0.00001240977,0.0003592377],"genre_scores_gemma":[0.9947477,0.000596863,0.003180209,0.00003377171,0.000004632329,0.000008271466,0.0006273085,0.00001219585,0.0007890311],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006627514,"threshold_uncertainty_score":0.002874255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.009769185075706618,"score_gpt":0.2471130777073279,"score_spread":0.2373438926316213,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}