{"id":"W4253549149","doi":"10.21203/rs.3.rs-550445/v1","title":"Endosomal traffic and glutamate synapse activity are increased in VPS35 D620N mutant knock-in mouse neurons, and resistant to LRRK2 kinase inhibition","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Retinal Development and Disorders","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of British Columbia","funders":"Fonds de Recherche du Québec - Santé; Parkinson Canada; Canadian Institutes of Health Research; McGill University; Killam Trusts; Parkinson Society Canada","keywords":"LRRK2; Mutant; Synapse; Cell biology; Glutamate receptor; Endosome; Knockout mouse; Chemistry; Neuroscience; Biology; Mutation; Biochemistry; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001542979,0.0007489042,0.0004221371,0.0007447774,0.000232879,0.0004243377,0.0003249494,0.0006129418,0.001885957],"category_scores_gemma":[0.0001389485,0.0003716557,0.0004079237,0.000219323,0.0004432579,0.0002762943,0.0002506358,0.000651542,0.0005607404],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004355413,"about_ca_system_score_gemma":0.0001376815,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008904779,"about_ca_topic_score_gemma":0.001254576,"domain_scores_codex":[0.9997385,0.00002198661,0.00005195822,0.00007586888,0.00006693171,0.00004464008],"domain_scores_gemma":[0.999765,0.0000169285,0.00009194897,0.00001640758,0.00001872696,0.00009091345],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00006823764,0.00001342375,0.0001239123,0.00001695019,0.000006610909,0.00007469779,0.00001110005,0.00001840529,0.9994326,0.00003027758,0.00001821887,0.0001856132],"study_design_scores_gemma":[0.00003910955,0.0003165021,0.01449885,0.00001590798,0.00004637364,0.001362002,0.00006297804,0.0009731787,0.981189,0.0001194375,0.00136579,0.00001098326],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9967997,0.0006714058,0.001126515,0.00007773899,0.0000254039,0.00001130043,0.0005803693,0.00009756225,0.0006099397],"genre_scores_gemma":[0.9919459,0.0006168928,0.002167137,0.00008435114,0.00001057089,0.00004909963,0.0009339349,0.00008446712,0.004107656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001885957,"threshold_uncertainty_score":0.006309152,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02085796756312033,"score_gpt":0.309252043633824,"score_spread":0.2883940760707037,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}