{"id":"W4253853436","doi":"10.1002/ange.202012520","title":"Going Platinum to the Tune of a Remarkable Guanine Quadruplex Binder: Solution‐ and Solid‐State Investigations.","year":2020,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Queen's University","funders":"Natural Sciences and Engineering Research Council of Canada; Mitacs","keywords":"Guanine; G-quadruplex; Platinum; Chemistry; Nucleic acid; Solid-state; Ligand (biochemistry); Combinatorial chemistry; Duplex (building); Selectivity; DNA; Stereochemistry; Biochemistry; Nucleotide; Catalysis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001175409,0.0001483266,0.0001340075,0.00006773071,0.0001084047,0.0002796183,0.0003147097,0.0003074079,0.001861167],"category_scores_gemma":[0.0002390845,0.0001138209,0.00007764495,0.0001032163,0.0002158508,0.0002550536,0.0002046994,0.0005139295,0.0003206704],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002464282,"about_ca_system_score_gemma":0.00009585338,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004165765,"about_ca_topic_score_gemma":0.000743542,"domain_scores_codex":[0.9999241,0.00000903838,0.000003201572,0.00001825434,0.00003191456,0.00001344938],"domain_scores_gemma":[0.9999578,0.00001287575,0.00000940574,0.000004946636,0.000007174074,0.000007789055],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001010046,0.00004974883,0.0001067383,0.0001122835,0.00001350767,0.00008946372,0.00007637292,0.0002186899,0.9930841,0.001003363,0.0004323547,0.004712412],"study_design_scores_gemma":[0.00002265171,0.0003872994,0.0003716995,0.000007192651,0.00001133396,0.0001701721,0.00004516291,0.001429491,0.990389,0.0001935953,0.006963486,0.000008839665],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9850647,0.002640384,0.005171985,0.0002877028,0.00005329249,0.00003786572,0.0001711763,0.0001028836,0.006470008],"genre_scores_gemma":[0.9938005,0.0008681109,0.001989572,0.00006238789,0.00001168128,0.00001200204,0.0001721525,0.000015457,0.003068186],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001861167,"threshold_uncertainty_score":0.006226182,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01662440358326732,"score_gpt":0.237867636787272,"score_spread":0.2212432332040047,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}