{"id":"W4253866636","doi":"10.26434/chemrxiv.14517063.v1","title":"Total Syntheses of the C19 Diterpenoid Alkaloids (–)-Talatisamine, (–)-Liljestrandisine, and (–)-Liljestrandinine by a Fragment Coupling Approach","year":2021,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Plant-based Medicinal Research","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Heritage Medical Research Institute; Natural Sciences and Engineering Research Council of Canada; California Institute of Technology; National Institutes of Health; National Science Foundation","keywords":"Fragment (logic); Terpenoid; Stereochemistry; Chemistry; Aconitine; Coupling (piping); Computer science; Chromatography; Algorithm; Materials science","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow","research_integrity"],"consensus_categories":[],"category_scores_codex":[0.00133291,0.0006582691,0.00104756,0.0001523049,0.0002594663,0.0000814168,0.0007822083,0.001069512,0.0008391303],"category_scores_gemma":[0.0007729037,0.000510517,0.0003045391,0.0003196708,0.001025268,0.00008582135,0.0009314846,0.00336055,0.00000637663],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001102544,"about_ca_system_score_gemma":0.0008104855,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000917028,"about_ca_topic_score_gemma":0.00002806612,"domain_scores_codex":[0.9963278,0.000322442,0.000824797,0.0009715099,0.0007573137,0.0007961319],"domain_scores_gemma":[0.9966246,0.001539434,0.0004306904,0.0007438447,0.0001989124,0.0004625364],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00307832,0.0052582,0.09515931,0.01284641,0.004325486,0.0005188721,0.004236221,0.01004518,0.8284298,0.0004913859,0.02181712,0.01379371],"study_design_scores_gemma":[0.00898927,0.0006512862,0.03090851,0.003994669,0.003100139,0.0007912031,0.001971628,0.0636235,0.8702466,0.0003245385,0.01258681,0.00281178],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9840322,0.008038011,0.0005263556,0.0009520125,0.001058121,0.00117402,0.0004724171,0.00006469166,0.003682128],"genre_scores_gemma":[0.995195,0.001991173,0.0004458624,0.0002398543,0.0003090789,0.0001605934,0.0005545747,0.00007205038,0.001031864],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0642508,"threshold_uncertainty_score":0.9997346,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.09427760937578983,"score_gpt":0.3915926137644434,"score_spread":0.2973150043886535,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}