{"id":"W4253948839","doi":"10.1016/j.molcel.2012.05.013","title":"OTUB1 Co-opts Lys48-Linked Ubiquitin Recognition to Suppress E2 Enzyme Function","year":2012,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":7,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto Metropolitan University; University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Linker; Biology; Fusion protein; Protein Data Bank (RCSB PDB); Protein Data Bank; Protein subunit; Biochemistry; Peptide sequence; Protein structure; Computational biology; Bioinformatics; Computer science; Gene; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002994145,0.0006973642,0.0005389836,0.0004057961,0.0006239533,0.001007206,0.0007702851,0.0008772296,0.004201591],"category_scores_gemma":[0.0002633008,0.0003395236,0.0004747785,0.0004147433,0.0006148278,0.0004945384,0.0005982093,0.001556047,0.002103104],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001056286,"about_ca_system_score_gemma":0.0005514848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008576731,"about_ca_topic_score_gemma":0.001978201,"domain_scores_codex":[0.9995746,0.00004294035,0.00004337825,0.00009978961,0.0001305686,0.0001086739],"domain_scores_gemma":[0.9996932,0.0000571702,0.00007130475,0.00006568932,0.00002000248,0.00009269195],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003236861,0.00007673172,0.0002111295,0.00005455377,0.00001258575,0.0001083279,0.00001204461,0.0001387209,0.9953271,0.0006061568,0.0003721768,0.002756726],"study_design_scores_gemma":[0.00001408799,0.00003334476,0.000598549,0.000002210261,0.000005849071,0.0001301525,0.00001407105,0.0006919617,0.9955384,0.00006628148,0.002900438,0.000004583967],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9780002,0.001958257,0.009433942,0.0006824341,0.000423826,0.00007519246,0.001434037,0.000724696,0.007267409],"genre_scores_gemma":[0.9887375,0.0003566391,0.003217512,0.0001506737,0.0000270906,0.00004966499,0.0008189212,0.000218625,0.00642335],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004201591,"threshold_uncertainty_score":0.01405573,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0186377062375681,"score_gpt":0.2484181627170809,"score_spread":0.2297804564795128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}