{"id":"W4253981040","doi":"10.14740/jmc1985w","title":"A Case of Crizotinib-Resistant Lung Adenocarcinoma Harboring a KRAS Mutation and an EML4-ALK Fusion Gene","year":2014,"lang":"en","type":"article","venue":"Journal of Medical Cases","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Crizotinib; Anaplastic lymphoma kinase; Medicine; KRAS; Cancer research; Fusion gene; Adenocarcinoma; Lung cancer; Mutation; Gene; Oncology; Cancer; Internal medicine; Genetics; Biology; Colorectal cancer","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003880789,0.001465023,0.001120935,0.003003617,0.002639891,0.001737992,0.001041188,0.005123049,0.003280391],"category_scores_gemma":[0.002513153,0.001004216,0.001423594,0.001694668,0.00135765,0.001996006,0.00159951,0.003210303,0.001340219],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001250193,"about_ca_system_score_gemma":0.001019429,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002582041,"about_ca_topic_score_gemma":0.004129532,"domain_scores_codex":[0.9992094,0.00007665026,0.0001064038,0.0001952184,0.000143147,0.0002691612],"domain_scores_gemma":[0.998664,0.0002781099,0.000334172,0.0001335017,0.0001022132,0.0004878938],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"case_report","study_design_gemma":"case_report","study_design_scores_codex":[0.00001699619,0.00001375772,0.002232221,0.0000185101,0.00000538893,0.9959883,0.0000480028,0.00003696007,0.0007231505,0.0001026733,0.0001191378,0.0006948256],"study_design_scores_gemma":[0.000003867116,0.00001377684,0.0008640771,0.000003710141,0.000007536363,0.9983703,0.00003395216,0.0000811355,0.0002461323,0.00006452734,0.0003073106,0.000003578405],"study_design_candidate":"case_report","study_design_consensus":"case_report","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9394441,0.01477339,0.007424898,0.00765017,0.0007385304,0.0002765789,0.000470214,0.0004622072,0.02875993],"genre_scores_gemma":[0.9906124,0.002406524,0.002687248,0.0009171102,0.0006953711,0.00003076029,0.000112872,0.00003006191,0.002507671],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005123049,"threshold_uncertainty_score":0.01097405,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0249529478765331,"score_gpt":0.3611480030142384,"score_spread":0.3361950551377053,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}