{"id":"W4254135320","doi":"10.1002/ange.201803254","title":"Metabolic Inhibitors of O‐GlcNAc Transferase That Act In Vivo Implicate Decreased O‐GlcNAc Levels in Leptin‐Mediated Nutrient Sensing","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":9,"is_retracted":false,"has_abstract":true,"ca_institutions":"Okanagan University College; University of British Columbia, Okanagan Campus; Kelowna General Hospital; University of British Columbia; Simon Fraser University","funders":"Canadian Glycomics Network; Michael Smith Health Research BC; Natural Sciences and Engineering Research Council of Canada; Wellcome Trust","keywords":"Serine; In vivo; Transferase; N-Acetylglucosamine; Glycosylation; Threonine; Biochemistry; Chemistry; Enzyme; Leptin; In vitro; Glycosyltransferase; Nutrient sensing; Biology; Cell biology; Signal transduction; Endocrinology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001901135,0.0006472027,0.0002514528,0.0002426105,0.0001421305,0.0002034204,0.0002142184,0.0002804464,0.00162902],"category_scores_gemma":[0.0001453153,0.0001887667,0.0002526977,0.0001814587,0.0002965534,0.0002173317,0.0001252561,0.0006326323,0.0003226902],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003117794,"about_ca_system_score_gemma":0.0003027678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005613926,"about_ca_topic_score_gemma":0.001037231,"domain_scores_codex":[0.9998534,0.00004408554,0.00001188419,0.00002678078,0.00003033161,0.00003351107],"domain_scores_gemma":[0.9998412,0.00003870253,0.00004794875,0.00002032501,0.0000116587,0.0000401649],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002683338,0.00004087668,0.00005654409,0.00001618372,0.000004557603,0.00001756351,0.000003658458,0.00003360843,0.9989936,0.00006865935,0.00002011089,0.0004764206],"study_design_scores_gemma":[0.00001516993,0.0003981488,0.0004680824,0.000001578536,0.000006181257,0.00004357662,0.000003468906,0.0001644279,0.9984688,0.00001307835,0.0004164363,0.000001102717],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9881651,0.001878461,0.006331307,0.0001479464,0.00008689261,0.00007072549,0.00051262,0.0002025897,0.002604137],"genre_scores_gemma":[0.9862469,0.00172618,0.007336521,0.0001001453,0.00002130883,0.0001222517,0.0009045654,0.00005890423,0.003483275],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00162902,"threshold_uncertainty_score":0.005449653,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02662337688741858,"score_gpt":0.2855477886998334,"score_spread":0.2589244118124149,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}