{"id":"W4254148815","doi":"10.1002/ange.201407135","title":"Reversible Ca<sup>2+</sup> Switch of An Engineered Allosteric Antioxidant Selenoenzyme","year":2014,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Organoselenium and organotellurium chemistry","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":8,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université Laval","funders":"","keywords":"Chemistry; Antioxidant; Glutathione; Glutathione peroxidase; Allosteric regulation; Selenium; Biophysics; Biochemistry; Enzyme; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007566685,0.0002077286,0.000182372,0.00004100294,0.00007609167,0.0002651605,0.0002575154,0.0002288097,0.0009378702],"category_scores_gemma":[0.0001270267,0.00008413352,0.000127837,0.00006598692,0.0001730352,0.0001803103,0.0001731123,0.0002483148,0.0002194192],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001817852,"about_ca_system_score_gemma":0.000107973,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002384128,"about_ca_topic_score_gemma":0.0002770731,"domain_scores_codex":[0.9999629,0.000005815199,0.00000202419,0.00001343,0.000007891319,0.000007941419],"domain_scores_gemma":[0.9999728,0.000006545056,0.000007343507,0.000004121881,0.00000432149,0.000004831175],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001711355,0.00004192249,0.0003100124,0.00007226825,0.00001601784,0.0001068175,0.00002941099,0.002393823,0.9906589,0.001307736,0.0001761131,0.004715892],"study_design_scores_gemma":[0.00005101429,0.0001741785,0.0004575323,0.000003579546,0.00001706895,0.0001096486,0.00002411404,0.01603656,0.9786375,0.000235755,0.004241973,0.00001118102],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9882843,0.0002541991,0.009007479,0.00009976895,0.00002933865,0.0000175395,0.00005839051,0.0002061207,0.002042767],"genre_scores_gemma":[0.9942677,0.0001124937,0.004436751,0.00002948718,0.000002560981,0.00001153856,0.00004325874,0.00002598604,0.001070212],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009378702,"threshold_uncertainty_score":0.003137529,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03472374063737056,"score_gpt":0.3181472425490892,"score_spread":0.2834235019117186,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}