{"id":"W4254838725","doi":"10.1210/en.142.2.907","title":"Parathyroid Hormone-Induced Up-Regulation of Connexin-43 Messenger Ribonucleic Acid (mRNA) Is Mediated by Sequences within Both the Promoter and the 3'Untranslated Region of the mRNA","year":2001,"lang":"en","type":"article","venue":"Endocrinology","topic":"Connexins and lens biology","field":"Biochemistry, Genetics and Molecular Biology","cited_by":5,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Lunenfeld-Tanenbaum Research Institute; Mount Sinai Hospital","funders":"","keywords":"Untranslated region; Luciferase; Messenger RNA; Molecular biology; Three prime untranslated region; Biology; Parathyroid hormone; Promoter; Forskolin; Enhancer; Transcriptional regulation; Reporter gene; Gene expression; Transfection; Gene; Internal medicine; Cell culture; Genetics; Calcium; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000139219,0.0002411967,0.0002527796,0.0001930344,0.0001415336,0.0001885003,0.00007601653,0.0001312215,0.001350445],"category_scores_gemma":[0.0001475678,0.0001599052,0.0002771932,0.0001314347,0.0003037242,0.000132424,0.0002297478,0.0003765803,0.0002477324],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002107624,"about_ca_system_score_gemma":0.0002237568,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004141773,"about_ca_topic_score_gemma":0.0009358231,"domain_scores_codex":[0.9998174,0.00002377042,0.00001278492,0.00004828165,0.00006690751,0.00003090768],"domain_scores_gemma":[0.9998747,0.00004060337,0.0000330253,0.000009736318,0.00001254713,0.0000293886],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001221924,0.000003656841,0.00006722424,0.00001150077,7.946085e-7,0.00002640172,0.000009118067,0.000005507476,0.9995277,0.00002372008,0.000005442715,0.0003067308],"study_design_scores_gemma":[0.00001119837,0.0002677161,0.02292739,0.00000738188,0.00001036239,0.0003129518,0.00004372108,0.0002573977,0.9737717,0.00008662059,0.002297451,0.000006232556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9919285,0.002349083,0.00349259,0.00008642079,0.00004903461,0.00002645163,0.0002704538,0.00007313462,0.001724229],"genre_scores_gemma":[0.9914153,0.001568722,0.003362988,0.00004825812,0.00002031763,0.00003572234,0.0004022521,0.00002425155,0.003122128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001350445,"threshold_uncertainty_score":0.004517674,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01350661307498448,"score_gpt":0.2362771202546979,"score_spread":0.2227705071797134,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}