{"id":"W4254889096","doi":"10.1093/annonc/mdw594.001","title":"437O KEYNOTE-024: Pembrolizumab (pembro) vs platinum-based chemotherapy (chemo) as first-line therapy for advanced NSCLC with a PD-L1 tumor proportion score (TPS) ≥50%","year":2016,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Cancer Immunotherapy and Biomarkers","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Kingston General Hospital","funders":"","keywords":"Pembrolizumab; Medicine; Oncology; Internal medicine; Chemotherapy; Cancer; Immunotherapy","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00107852,0.0006423677,0.001168632,0.0003936508,0.0002903045,0.001095242,0.00103062,0.00171123,0.02198663],"category_scores_gemma":[0.001405232,0.0003125652,0.001596133,0.0003829627,0.0003493838,0.0008159077,0.0004507068,0.003484123,0.002992055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001262314,"about_ca_system_score_gemma":0.001275212,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001416247,"about_ca_topic_score_gemma":0.004488604,"domain_scores_codex":[0.9997174,0.0001056593,0.00002526302,0.00005037529,0.00003098977,0.0000702441],"domain_scores_gemma":[0.9993365,0.0001716046,0.000104439,0.00002453645,0.00004437358,0.0003184956],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.780917,0.004865151,0.002391527,0.001437239,0.001606783,0.0002165662,0.00006970835,0.001300367,0.008095894,0.001157604,0.04868355,0.1492585],"study_design_scores_gemma":[0.7415822,0.1410006,0.02628555,0.0008455825,0.00570873,0.0006131217,0.0001695663,0.00410181,0.005434458,0.001832256,0.07233161,0.00009459721],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8349054,0.03491056,0.001540426,0.02849225,0.01664191,0.004244773,0.01746099,0.0004778916,0.06132591],"genre_scores_gemma":[0.9243475,0.01120008,0.002758753,0.01119737,0.005891846,0.001642243,0.008216535,0.0001319525,0.03461367],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02198663,"threshold_uncertainty_score":0.07355261,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04872773898541408,"score_gpt":0.3537473033666244,"score_spread":0.3050195643812103,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}