{"id":"W4254927923","doi":"10.21203/rs.3.rs-152131/v1","title":"Inhibition of lipid metabolism exerts antitumor effects on rhabdomyosarcoma","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Cancer, Lipids, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Cancer Research Institute","keywords":"Lipid metabolism; AMPK; Glycolysis; Warburg effect; Metabolism; Fatty acid metabolism; Apoptosis; Beta oxidation; Autophagy; Rhabdomyosarcoma; Cell growth; Chemistry; Hexokinase; Pentose phosphate pathway; Kinase; Downregulation and upregulation; Carbohydrate metabolism; Endocrinology; Biology; Internal medicine; Protein kinase A; Biochemistry; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008004059,0.0003264986,0.0002176102,0.0002593263,0.00009402882,0.0001014997,0.00009704051,0.0001284026,0.0008313681],"category_scores_gemma":[0.00003759215,0.00006121516,0.0001777531,0.0001241124,0.0001238967,0.0000861318,0.00009071628,0.0003072371,0.0001933344],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001378125,"about_ca_system_score_gemma":0.0001723351,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002860239,"about_ca_topic_score_gemma":0.0005299943,"domain_scores_codex":[0.9999564,0.000007765754,0.000004492939,0.000007913483,0.000009715111,0.00001371355],"domain_scores_gemma":[0.9999694,0.000004443152,0.000009915795,0.000003623091,0.000004112918,0.000008536153],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003399512,0.0001137478,0.0003219752,0.0000560256,0.000006798057,0.00003506424,0.000004801339,0.00008600277,0.9960679,0.00005013039,0.00005272719,0.002864932],"study_design_scores_gemma":[0.00005061656,0.001433357,0.006557399,0.000007075121,0.00003199176,0.0001359618,0.00001395214,0.0004258367,0.9896502,0.0000338186,0.001656533,0.000003330698],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947261,0.002506889,0.0009488116,0.00008224921,0.00002034778,0.00002588178,0.0002871089,0.00006875286,0.001333842],"genre_scores_gemma":[0.9957404,0.001732221,0.000852166,0.00003428136,0.000009004556,0.00003676465,0.0004000338,0.000008025983,0.001187153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008313681,"threshold_uncertainty_score":0.002781212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0231381780795637,"score_gpt":0.3381355162634535,"score_spread":0.3149973381838898,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}