{"id":"W4254986934","doi":"10.1002/ange.201804351","title":"Total Synthesis Establishes the Biosynthetic Pathway to the Naphterpin and Marinone Natural Products","year":2018,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Bioactive Compounds and Antitumor Agents","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":12,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institutes of Health; Australian Research Council; Canadian Network for Research and Innovation in Machining Technology, Natural Sciences and Engineering Research Council of Canada","keywords":"Biosynthesis; Chemistry; Halogenation; Total synthesis; Stereochemistry; Biomimetic synthesis; Enzyme; Chlorine; Natural product; Biochemistry; Organic chemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005101641,0.0002205978,0.0001811195,0.00004112511,0.0006224227,0.00009407845,0.0003676295,0.0001107225,0.0003088783],"category_scores_gemma":[0.0002571652,0.0001206583,0.00005896837,0.0002765695,0.0005904746,0.0001014187,0.0002787134,0.0003807351,0.0001310613],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002968001,"about_ca_system_score_gemma":0.00004070073,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003508994,"about_ca_topic_score_gemma":0.00004238183,"domain_scores_codex":[0.9987478,0.0001509551,0.0001729146,0.0003752465,0.0001431314,0.0004099987],"domain_scores_gemma":[0.9990211,0.0003513349,0.00006876704,0.0003267366,0.0001204269,0.0001116266],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003730339,0.0002224989,0.004446556,0.00006012883,0.0002831928,0.00003241833,0.00195517,8.305796e-7,0.902213,0.0003830199,0.05186899,0.03816114],"study_design_scores_gemma":[0.0001700303,0.00004672692,0.006261518,0.00001663591,0.00006121005,0.00006276165,0.0001795834,0.00002286291,0.7657385,0.00003998768,0.2272431,0.0001570559],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9737072,0.001232748,0.000006599119,0.01611594,0.00144942,0.0004028935,0.00005943569,0.00005842743,0.006967332],"genre_scores_gemma":[0.9931251,0.0001161682,0.00008274571,0.002938356,0.001002821,0.00006420683,0.000005531748,0.0000205863,0.002644482],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.1753742,"threshold_uncertainty_score":0.4920301,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06363162501486763,"score_gpt":0.3449592363657979,"score_spread":0.2813276113509303,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}