{"id":"W4255097239","doi":"10.21203/rs.3.rs-538054/v1","title":"Efficacy of Fulvestrant in Women with Hormone-Resistant Metastatic Breast Cancer (mBC): A Canadian Province Experience","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Advanced Breast Cancer Therapies","field":"Medicine","cited_by":4,"is_retracted":false,"has_abstract":false,"ca_institutions":"Saskatchewan Cancer Agency; University of Saskatchewan","funders":"Mach-Gaensslen Foundation of Canada; Saskatchewan Cancer Agency; University of Saskatchewan","keywords":"Fulvestrant; Metastatic breast cancer; Oncology; Medicine; Internal medicine; Breast cancer; Gynecology; Cancer; Estrogen receptor","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":true,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007485639,0.0004337985,0.001025895,0.0008952394,0.0001113209,0.00008229047,0.0004950856,0.0001793194,0.0004172731],"category_scores_gemma":[0.0001698938,0.0003566534,0.0001007719,0.001163966,0.0007076765,0.0001515147,0.0003025185,0.001764108,0.000003541937],"about_ca_system_candidate":true,"about_ca_system_consensus":true,"about_ca_system_score_codex":0.004487504,"about_ca_system_score_gemma":0.0166868,"about_ca_topic_candidate":true,"about_ca_topic_consensus":true,"about_ca_topic_score_codex":0.2840369,"about_ca_topic_score_gemma":0.2659131,"domain_scores_codex":[0.9948564,0.0003483198,0.0005832143,0.001022544,0.001698011,0.001491497],"domain_scores_gemma":[0.9965112,0.0002053334,0.0001769486,0.001200824,0.001003842,0.0009018555],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"observational","study_design_scores_codex":[0.1288894,0.006609112,0.05587667,0.04198784,0.004340571,0.033275,0.212223,0.012516,0.139365,0.0005753553,0.0002801668,0.364062],"study_design_scores_gemma":[0.007163166,0.001435931,0.9349371,0.01569979,0.00007754338,0.0002580945,0.03516595,0.0001872158,0.002452262,0.0001279398,0.001688768,0.0008063079],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9858479,0.008749582,0.00006180013,0.00181534,0.00005034809,0.002554209,0.0006895176,0.00003466379,0.0001966215],"genre_scores_gemma":[0.9955181,0.0008523121,0.001108567,0.00007099895,0.00009098893,0.002008802,0.00005995397,0.00009498534,0.0001953153],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8790604,"threshold_uncertainty_score":0.9998885,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04034945561232564,"score_gpt":0.3822747702368161,"score_spread":0.3419253146244904,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}