{"id":"W4255273450","doi":"10.1016/j.annonc.2020.10.349","title":"356MO Osimertinib adjuvant therapy in patients (pts) with resected EGFR-mutated (EGFRm) NSCLC (ADAURA): Central nervous system (CNS) disease recurrence","year":2020,"lang":"en","type":"article","venue":"Annals of Oncology","topic":"Lung Cancer Treatments and Mutations","field":"Medicine","cited_by":5,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; University of Toronto; University Health Network","funders":"Chugai Pharmaceutical; Eli Lilly Japan; AstraZeneca; Eli Lilly and Company","keywords":"Osimertinib; Medicine; Internal medicine; Oncology; Adjuvant; Hazard ratio; Discontinuation; Adenocarcinoma; Cancer; Confidence interval","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009773814,0.0001281356,0.0002920066,0.0001460882,0.0001696033,0.0002751773,0.00008937132,0.0001917279,0.001579606],"category_scores_gemma":[0.0002239378,0.00007521671,0.0002987378,0.0001927686,0.00007485336,0.0001615817,0.0001102436,0.0002143739,0.0001519604],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002576576,"about_ca_system_score_gemma":0.0003267378,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001779763,"about_ca_topic_score_gemma":0.008625275,"domain_scores_codex":[0.9999558,0.000008801569,0.000005157469,0.000008391846,0.000005790956,0.00001603671],"domain_scores_gemma":[0.9999418,0.00000888992,0.00001941884,0.000001528988,0.000003750584,0.00002466429],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.01707178,0.0005758464,0.8560677,0.0002663812,0.0004459914,0.003277821,0.0001416284,0.0006113472,0.009554774,0.0001941674,0.003747551,0.108045],"study_design_scores_gemma":[0.0006953196,0.00611635,0.9794276,0.00008578868,0.0006252332,0.004123132,0.0002129461,0.001154329,0.00129788,0.000176364,0.006071056,0.0000141084],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955863,0.002141819,0.00003728598,0.0001752802,0.00003959544,0.00001195163,0.0001788134,0.000004974091,0.001823968],"genre_scores_gemma":[0.9980996,0.0007307953,0.00006000891,0.0001365082,0.00004463198,0.000007138263,0.0002508092,0.000001079912,0.0006694982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001779763,"threshold_uncertainty_score":0.005284309,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05058576355198821,"score_gpt":0.3667156560000392,"score_spread":0.316129892448051,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}