{"id":"W4255564297","doi":"10.22215/etd/2016-11720","title":"The in vivo Use of Dopamine Binding Aptamers in a Mouse Model of Dopamine Dysregulation","year":2016,"lang":"en","type":"dissertation","venue":"","topic":"Lipid Membrane Structure and Behavior","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Aptamer; Transferrin receptor; Pharmacology; Systemic administration; Chemistry; Dopamine; Liposome; In vivo; Central nervous system; Dopaminergic; Transferrin; Neuroscience; Cell biology; Medicine; Biology; Molecular biology; Biochemistry; Biotechnology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007909377,0.00140128,0.0005629854,0.001622975,0.00047983,0.0007023226,0.0006601253,0.001698804,0.002578362],"category_scores_gemma":[0.0002440489,0.0006042865,0.0007426636,0.0003862522,0.0008456623,0.0006792108,0.0003317103,0.002431477,0.000950985],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007212837,"about_ca_system_score_gemma":0.0004493891,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008407452,"about_ca_topic_score_gemma":0.001638411,"domain_scores_codex":[0.9994097,0.00009482228,0.0000623614,0.0002223495,0.0001102734,0.0001005526],"domain_scores_gemma":[0.9996341,0.00005300416,0.0001103859,0.00006310724,0.00004347779,0.00009592642],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002441619,0.0002360115,0.0001144019,0.0000297281,0.000008313986,0.00007664891,0.00003140084,0.00007414755,0.9977684,0.0001974988,0.0000849481,0.001134282],"study_design_scores_gemma":[0.00007194903,0.00177468,0.001152581,0.0000155908,0.00003633613,0.0003637713,0.00004115982,0.0007214107,0.9927482,0.0001271571,0.0029373,0.000009895989],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9504583,0.002848553,0.03515044,0.001197039,0.0005200214,0.0009789726,0.002838484,0.0009640878,0.005044094],"genre_scores_gemma":[0.9169483,0.004274424,0.04261148,0.0004810842,0.0000757161,0.002100915,0.002500119,0.0003304769,0.03067738],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002578362,"threshold_uncertainty_score":0.008625448,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01466165863381718,"score_gpt":0.2579811727386561,"score_spread":0.2433195141048389,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}