{"id":"W4255569255","doi":"10.1038/npg.els.0003004","title":"Protein Unfolding and Denaturants","year":2003,"lang":"en","type":"other","venue":"Encyclopedia of Life Sciences","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Polypeptide chain; Urea; Biophysics; Protein folding; Protein structure; Crystallography; Biochemistry; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001533894,0.0001617152,0.0001863743,0.00008794352,0.00004870351,0.00001032013,0.0002296234,0.0002377654,0.00007080279],"category_scores_gemma":[0.0001626176,0.0001294301,0.00003774868,0.0001127829,0.0003524953,0.000002482398,0.00007778826,0.00007260223,0.00000243633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000002043246,"about_ca_system_score_gemma":0.0001693108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00004151624,"about_ca_topic_score_gemma":0.00005871431,"domain_scores_codex":[0.999118,0.00003465001,0.0001483932,0.0003434597,0.0001782067,0.0001772883],"domain_scores_gemma":[0.9995621,0.000005299081,0.0001718382,0.000173077,0.00001588096,0.00007179341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00009042397,0.0001330193,0.02435409,0.001197526,0.0003867042,0.00001859308,0.0002181697,0.00002376049,0.1273973,0.008804594,0.8085608,0.02881496],"study_design_scores_gemma":[0.0002500681,0.0001759687,0.0001836771,0.0001301379,0.00001613104,0.000007700412,0.00004535138,0.000006943778,0.004337959,0.0005183173,0.9939641,0.0003636838],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"other","genre_gemma":"other","genre_scores_codex":[0.0305846,0.01956748,0.0002275197,0.000043275,0.000362599,0.0003698675,0.00003374366,0.00001662082,0.9487943],"genre_scores_gemma":[0.08943576,0.01349745,0.03086855,0.000441487,0.00124884,0.00005596795,0.00005417695,0.0002857076,0.864112],"genre_candidate":"other","genre_consensus":"other","teacher_disagreement_score":0.1854032,"threshold_uncertainty_score":0.5278006,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00623342006593604,"score_gpt":0.2398737269540486,"score_spread":0.2336403068881125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}