{"id":"W4255569255","doi":"10.1038/npg.els.0003004","title":"Protein Unfolding and Denaturants","year":2003,"lang":"en","type":"other","venue":"Encyclopedia of Life Sciences","topic":"Protein Structure and Dynamics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"","keywords":"Chemistry; Polypeptide chain; Urea; Biophysics; Protein folding; Protein structure; Crystallography; Biochemistry; Amino acid; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003828052,0.001140256,0.000649114,0.0007602988,0.0007963986,0.0006152786,0.0007545839,0.0004647089,0.01179951],"category_scores_gemma":[0.0003956061,0.0003362952,0.0004140773,0.001016878,0.0003695618,0.0004477128,0.0005127488,0.001819358,0.006056101],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006167784,"about_ca_system_score_gemma":0.0004563638,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001762535,"about_ca_topic_score_gemma":0.002326767,"domain_scores_codex":[0.9994603,0.00006063177,0.00004408561,0.0001812213,0.0001789787,0.00007478061],"domain_scores_gemma":[0.9998634,0.00002799086,0.00002852791,0.00002147284,0.00004066786,0.00001805152],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0005979018,0.0002178795,0.0004348642,0.001522798,0.0000338469,0.0003404257,0.0001211157,0.0004634882,0.9395796,0.004348186,0.00800224,0.04433766],"study_design_scores_gemma":[0.00002545408,0.0001527708,0.001274405,0.0001046774,0.00003026162,0.0002495084,0.00002203628,0.0003688927,0.8332918,0.0005363969,0.1639233,0.00002047779],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"other","genre_scores_codex":[0.4348699,0.218253,0.1298926,0.00338024,0.004916851,0.00323802,0.02433745,0.006856648,0.1742553],"genre_scores_gemma":[0.4290899,0.1267085,0.09270032,0.002243246,0.0004418259,0.003869161,0.03885389,0.001646974,0.3044462],"genre_candidate":"other","genre_consensus":null,"teacher_disagreement_score":0.01179951,"threshold_uncertainty_score":0.0394733,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00623342006593604,"score_gpt":0.2398737269540486,"score_spread":0.2336403068881125,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}