{"id":"W4255615995","doi":"10.1038/s41467-019-13070-z","title":"Multiple conformations facilitate PilT function in the type IV pilus","year":2019,"lang":"en","type":"article","venue":"Nature Communications","topic":"Biochemical and Structural Characterization","field":"Biochemistry, Genetics and Molecular Biology","cited_by":30,"is_retracted":false,"has_abstract":true,"ca_institutions":"SickKids Foundation; Hospital for Sick Children; McMaster University; University of Toronto","funders":"Canada Research Chairs; Government of Canada; Canadian Institutes of Health Research; Hospital for Sick Children; Government of Ontario","keywords":"Pilin; Pilus; Trimer; Chemistry; Crystallography; Protein structure; Mutant; Virulence; Biophysics; Biology; Biochemistry; Gene; Dimer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009931235,0.00007027244,0.00005552669,0.00002433545,0.00008875637,0.0000209533,0.00045364,0.0001882796,0.00001572936],"category_scores_gemma":[0.0001049103,0.00005070912,0.00003234612,0.0001714136,0.0000438476,0.000009381452,0.0001029581,0.0003272477,0.00004771617],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00000876187,"about_ca_system_score_gemma":0.00001844681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001048705,"about_ca_topic_score_gemma":0.0001255954,"domain_scores_codex":[0.9995339,0.0000702207,0.000131522,0.0001026227,0.00007146338,0.0000902864],"domain_scores_gemma":[0.9990182,0.00003903519,0.00004446936,0.0007864476,0.00009473731,0.00001709734],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001038589,0.00007279722,0.03203364,0.00001563987,0.00002591932,8.267649e-8,0.0004406284,0.00002824996,0.9572913,0.004947885,0.003410836,0.001629168],"study_design_scores_gemma":[0.000847903,0.0002017847,0.3325289,0.00001540548,0.00001962625,0.0000110785,0.0004569113,0.001885428,0.009578857,0.0005042122,0.653662,0.0002879684],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9926308,0.0009495571,0.00007038935,0.001882152,0.0001699103,0.0002685575,0.00003380518,0.00001236509,0.003982402],"genre_scores_gemma":[0.9967032,0.0001773417,0.0001983393,0.0009754613,0.00003171118,0.00001800457,0.001655554,0.000004569313,0.0002358362],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.9477124,"threshold_uncertainty_score":0.2067858,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01628696664009892,"score_gpt":0.2535942030534498,"score_spread":0.2373072364133509,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}