{"id":"W4255647328","doi":"10.3762/bxiv.2019.8.v1","title":"Design, synthesis and biological evaluation of immunostimulating mannosylated desmuramyl peptides","year":2019,"lang":"en","type":"preprint","venue":"","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"European Regional Development Fund; Medicinski Fakultet, Sveučilište u Zagrebu; Hrvatska Zaklada za Znanost; Terry Fox Foundation; Sveučilište u Zagrebu","keywords":"Muramyl dipeptide; Mannose; Peptidoglycan; Ovalbumin; Dipeptide; Chemistry; Peptide; Adamantane; Adjuvant; Lipophilicity; Biochemistry; Lipopeptide; Mannose receptor; Peptide synthesis; Linker; Immune system; Stereochemistry; In vitro; Biology; Cell wall; Immunology; Organic chemistry; Bacteria","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001933951,0.0003073408,0.0002124808,0.0001347859,0.00007999481,0.0001898729,0.0002166343,0.0002265743,0.0006458474],"category_scores_gemma":[0.0001371475,0.0001023404,0.0002037356,0.0001308221,0.0001308187,0.0001847463,0.0001315995,0.0002952954,0.0002290044],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000193241,"about_ca_system_score_gemma":0.0001376048,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001349282,"about_ca_topic_score_gemma":0.0001791595,"domain_scores_codex":[0.9999093,0.00002129124,0.000009997284,0.00001544872,0.00002689633,0.00001707616],"domain_scores_gemma":[0.9999112,0.00001095164,0.00002887978,0.000008032316,0.00001823719,0.00002272891],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001091166,0.00005926388,0.00005522268,0.00006584922,0.000005039813,0.00007486079,0.00001506813,0.0004849744,0.9961655,0.00007275455,0.0000153244,0.002877102],"study_design_scores_gemma":[0.0000378384,0.001434004,0.0004124662,0.000004259537,0.00001366707,0.0001386795,0.000007464542,0.0002629806,0.9953836,0.00002209662,0.002279172,0.000003741085],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922156,0.00211309,0.003954849,0.00005248826,0.00002558723,0.0001485086,0.0002167016,0.00002423916,0.001249032],"genre_scores_gemma":[0.9813965,0.002973557,0.01216874,0.00005109999,0.00002294978,0.00009117214,0.0005025745,0.00001491335,0.002778518],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0006458474,"threshold_uncertainty_score":0.002160549,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0815454171586625,"score_gpt":0.305982801139665,"score_spread":0.2244373839810025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}