{"id":"W4255918677","doi":"10.1172/jci200214036","title":"Targeted expression of a human pituitary tumor–derived isoform of FGF receptor-4 recapitulates pituitary tumorigenesis","year":2002,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Fibroblast Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":17,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; Ontario Institute for Cancer Research; University of Toronto; Mount Sinai Hospital","funders":"Medical Research Council; Medical Research Council Canada","keywords":"Biology; Gene isoform; Fibroblast growth factor receptor 4; Pituitary tumors; Carcinogenesis; Pituitary gland; Receptor; Cancer research; Fibroblast growth factor receptor; Cell biology; Fibroblast growth factor; Endocrinology; Cancer; Genetics; Gene; Hormone","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000509291,0.0006423408,0.0004854008,0.0006808518,0.000370221,0.0005260758,0.0005618969,0.0004632017,0.003377431],"category_scores_gemma":[0.0002193918,0.0004485567,0.0005610794,0.000380053,0.0005337066,0.0002048301,0.0003183426,0.0008216775,0.00139246],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007115109,"about_ca_system_score_gemma":0.0006526193,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00163549,"about_ca_topic_score_gemma":0.002673248,"domain_scores_codex":[0.999594,0.00005563042,0.00005749115,0.00008880175,0.0001199104,0.00008424186],"domain_scores_gemma":[0.9997099,0.00006225253,0.00007498935,0.00005874995,0.00002256133,0.00007156421],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001346561,0.00003506285,0.0001013239,0.00002786873,0.000006955776,0.0001336705,0.00001945662,0.0001166776,0.9987032,0.00010791,0.00009545345,0.0005177803],"study_design_scores_gemma":[0.000121508,0.0004721646,0.002347096,0.000008042671,0.00005545263,0.001151232,0.00005816637,0.001496338,0.9847893,0.00006320744,0.009422311,0.000015333],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9697326,0.001505731,0.01746698,0.0002081461,0.0001688818,0.000784958,0.006225975,0.0004777343,0.003428906],"genre_scores_gemma":[0.9607058,0.00144696,0.02203943,0.00009508995,0.00003992339,0.0007546279,0.006721594,0.000294841,0.00790175],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003377431,"threshold_uncertainty_score":0.01129866,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06421812979329598,"score_gpt":0.3458618203021743,"score_spread":0.2816436905088783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}