{"id":"W4255942265","doi":"10.1158/1538-7445.sabcs18-ct139","title":"Abstract CT139: NCI Molecular Analysis for Therapy Choice (NCI-MATCH EAY131) arm B: Phase II study of afatinib in patients (pts) with HER2 (ERBB2) activating mutations","year":2019,"lang":"en","type":"article","venue":"Clinical Trials","topic":"Chronic Lymphocytic Leukemia Research","field":"Medicine","cited_by":3,"is_retracted":false,"has_abstract":true,"ca_institutions":"Princess Margaret Cancer Centre","funders":"","keywords":"Afatinib; Medicine; Oncology; Internal medicine; Cancer; Epidermal growth factor receptor; Erlotinib","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007921114,0.0008454549,0.001149028,0.0004006982,0.0003735044,0.0006731921,0.0007340264,0.001030985,0.01453808],"category_scores_gemma":[0.0006911551,0.0002225205,0.0006758441,0.0004409077,0.0004888459,0.0005400414,0.0003404543,0.001907304,0.001438066],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001190382,"about_ca_system_score_gemma":0.001922419,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001327738,"about_ca_topic_score_gemma":0.002951162,"domain_scores_codex":[0.999716,0.0001271337,0.00001729057,0.00005675159,0.00003342394,0.0000494265],"domain_scores_gemma":[0.9995572,0.00006221602,0.00009105827,0.00002371626,0.0000248007,0.0002409793],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8265734,0.01696446,0.008701004,0.001160447,0.0008679262,0.0003543304,0.0001309324,0.002502115,0.03963227,0.001095698,0.0151475,0.08687],"study_design_scores_gemma":[0.8155438,0.1562188,0.01249081,0.00008403331,0.0003473037,0.0004612427,0.00002851438,0.001953245,0.004072885,0.0006345306,0.008136866,0.00002791464],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9748945,0.002723353,0.00101105,0.001315963,0.0001483106,0.00566396,0.004785514,0.0001939387,0.009263536],"genre_scores_gemma":[0.9748744,0.001190771,0.002576377,0.001690985,0.000184954,0.004802303,0.005669578,0.00005041169,0.00896019],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01453808,"threshold_uncertainty_score":0.04863471,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.2292891931188603,"score_gpt":0.5331464358580582,"score_spread":0.3038572427391979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}