{"id":"W4255970846","doi":"10.21203/rs.3.rs-25157/v2","title":"Depressive Effectiveness of Vigabatrin (y-Vinyl-GABA), an Antiepileptic Drug, in Intermediate-conductance Calcium-Activated Potassium Channels in Human Glioma Cells","year":2020,"lang":"en","type":"preprint","venue":"Research Square","topic":"Neuroscience and Neuropharmacology Research","field":"Neuroscience","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University","funders":"National Cheng Kung University Hospital; National Cheng Kung University; Ministry of Science and Technology, Taiwan","keywords":"Vigabatrin; Potassium; Glioma; Conductance; Drug; Calcium-activated potassium channel; Calcium; Chemistry; Antiepileptic drug; Potassium channel; Pharmacology; Epilepsy; Neuroscience; Biophysics; Medicine; Psychology; Biology; Anticonvulsant; Cancer research; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008002029,0.0001856721,0.0002260435,0.0001049087,0.00008185615,0.0002371235,0.0001907388,0.0002589663,0.0008084533],"category_scores_gemma":[0.00009321089,0.00007618838,0.0002330127,0.0001191455,0.0001309663,0.0001516337,0.0001191077,0.0003460932,0.0002332579],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000222515,"about_ca_system_score_gemma":0.0001347885,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001320194,"about_ca_topic_score_gemma":0.001052978,"domain_scores_codex":[0.9998876,0.00001918022,0.00001513987,0.00002217037,0.0000243333,0.00003159154],"domain_scores_gemma":[0.9999659,0.000006702548,0.000006421309,0.000004751468,0.000005041595,0.00001119109],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002734967,0.00003516796,0.0003274516,0.00004721911,0.000007856174,0.00005308304,0.00002039356,0.00004391645,0.9980904,0.0000598408,0.00005727234,0.0009838138],"study_design_scores_gemma":[0.00007616899,0.001232225,0.01898577,0.00001240849,0.00003524039,0.0002717442,0.00009534362,0.001370657,0.976095,0.0000509371,0.001767502,0.000006934018],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9964815,0.001688294,0.0004256603,0.0000531591,0.000027801,0.000009868364,0.0003080963,0.00002554241,0.000979994],"genre_scores_gemma":[0.9982536,0.0006110144,0.0002635989,0.00003251386,0.000003754407,0.00001395494,0.0002515762,0.000002557576,0.0005672213],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001320194,"threshold_uncertainty_score":0.002704501,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1208263422040452,"score_gpt":0.4365052494327398,"score_spread":0.3156789072286946,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}