{"id":"W4255993023","doi":"10.1200/jco.2017.35.15_suppl.tps1119","title":"SANDPIPER: Phase III study of the PI3-kinase (PI3K) inhibitor taselisib (GDC-0032) plus fulvestrant in patients (pts) with estrogen receptor (ER)-positive, HER2-negative locally advanced or metastatic breast cancer (BC) enriched for pts with <i>PIK3CA-</i>mutant tumors.","year":2017,"lang":"en","type":"article","venue":"Journal of Clinical Oncology","topic":"Cancer Treatment and Pharmacology","field":"Medicine","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ottawa Hospital","funders":"","keywords":"Fulvestrant; Medicine; Metastatic breast cancer; Aromatase inhibitor; Internal medicine; Cancer; Estrogen receptor; Placebo; Palbociclib; PI3K/AKT/mTOR pathway; Clinical endpoint; Oncology; Breast cancer; Cancer research; Randomized controlled trial; Aromatase; Biology; Pathology; Apoptosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000916116,0.001694206,0.001448053,0.0005584547,0.0003419073,0.000888722,0.001219093,0.001425688,0.005098069],"category_scores_gemma":[0.0007256282,0.0005938448,0.001249817,0.0004864044,0.001010099,0.0009156705,0.0003649122,0.00227724,0.0009918058],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001105534,"about_ca_system_score_gemma":0.002213678,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002062067,"about_ca_topic_score_gemma":0.005430229,"domain_scores_codex":[0.9997385,0.0001099893,0.0000109627,0.00004668734,0.00002559946,0.00006823594],"domain_scores_gemma":[0.9995558,0.0000675981,0.00009460831,0.0000365239,0.00002391364,0.0002215328],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"randomized_trial","study_design_scores_codex":[0.8441017,0.04415808,0.002628554,0.001091942,0.001421386,0.0001709786,0.0001730165,0.003437884,0.03878694,0.0004909412,0.005328525,0.05821005],"study_design_scores_gemma":[0.7312883,0.2560878,0.005086371,0.00003296595,0.0004504848,0.0001558214,0.00003716982,0.001434278,0.003308259,0.0002147101,0.001876984,0.00002681166],"study_design_candidate":"randomized_trial","study_design_consensus":"randomized_trial","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.985489,0.001580917,0.0009059379,0.000575781,0.0001524971,0.005363227,0.0026689,0.0004457747,0.002818149],"genre_scores_gemma":[0.9743316,0.001987186,0.003779718,0.001287624,0.0001861285,0.00737664,0.005241844,0.00005125447,0.005758106],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005098069,"threshold_uncertainty_score":0.01705474,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.05892864188827659,"score_gpt":0.4421185958734921,"score_spread":0.3831899539852155,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}