{"id":"W4256012484","doi":"10.22215/etd/2016-11465","title":"Elucidating Mechanisms of Action of Bioactive Substances by Chemical-Genetic Profiling","year":2016,"lang":"en","type":"dissertation","venue":"","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Carleton University","funders":"","keywords":"Mutant; Mode of action; Saccharomyces cerevisiae; Biology; Biochemistry; Gene; Phenotype; Cell biology; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002753592,0.0003049454,0.0002776725,0.0003062352,0.0001993918,0.0007912985,0.0002415444,0.000377286,0.001382115],"category_scores_gemma":[0.0003025955,0.0001444654,0.0004140654,0.0002389048,0.0003345193,0.0006415432,0.0003413513,0.0009858175,0.0006397226],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002869788,"about_ca_system_score_gemma":0.0004127393,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000211006,"about_ca_topic_score_gemma":0.0002486607,"domain_scores_codex":[0.9998499,0.0000172891,0.000009476481,0.00003224304,0.00005489462,0.00003600763],"domain_scores_gemma":[0.9998349,0.00003288105,0.00005533583,0.0000154498,0.00003637477,0.00002513261],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003443334,0.00001652501,0.0002608913,0.00003782552,0.000003119525,0.00002404853,0.00001626302,0.00006793048,0.9941239,0.0003754008,0.00004400233,0.004995628],"study_design_scores_gemma":[0.00000626905,0.0001819075,0.003026367,0.00001686878,0.00001661522,0.0001404276,0.00007500027,0.0005234181,0.9914815,0.0003791698,0.00414393,0.000008486953],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9279695,0.009929829,0.04702644,0.001424457,0.0003090931,0.0002349959,0.0009310217,0.0001685127,0.01200615],"genre_scores_gemma":[0.9224639,0.01304298,0.05051195,0.0008115467,0.0001003158,0.0001509931,0.0009367617,0.00007032413,0.01191137],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382115,"threshold_uncertainty_score":0.004623652,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01097049879675714,"score_gpt":0.2472890180175401,"score_spread":0.236318519220783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}