{"id":"W4256036356","doi":"10.1002/ange.201500598","title":"Amphiphilic Tobramycins with Immunomodulatory Properties","year":2015,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"Antimicrobial Peptides and Activities","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":true,"ca_institutions":"Health Sciences Centre; University of Manitoba","funders":"","keywords":"Lipopolysaccharide; Immune system; Innate immune system; Antibiotics; Septic shock; Bacteria; Amphiphile; Chemistry; Microbiology; Mode of action; Tumor necrosis factor alpha; Immunity; Biology; Cell biology; Sepsis; Immunology; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007080389,0.0002182204,0.00008947134,0.0001347798,0.0000989639,0.0001823838,0.00007168307,0.0002195429,0.0008309884],"category_scores_gemma":[0.000124281,0.00004159464,0.0001125906,0.0001120644,0.0001259954,0.0001367124,0.0001878365,0.0001935838,0.0002142366],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001110882,"about_ca_system_score_gemma":0.0001028529,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001543777,"about_ca_topic_score_gemma":0.0001639009,"domain_scores_codex":[0.9999466,0.00001525899,0.000003913347,0.000006452565,0.00000933227,0.00001846932],"domain_scores_gemma":[0.9998972,0.00001456635,0.00002936974,0.00001174948,0.0000120917,0.00003508031],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008532297,0.00001283648,0.0001345947,0.00001942338,0.000002224704,0.00003440853,0.000005125891,0.00008179983,0.9980407,0.0001573879,0.00002621573,0.001399949],"study_design_scores_gemma":[0.00001852304,0.0003404693,0.001853738,0.00000625078,0.000007896031,0.0001999886,0.00001121854,0.0005222572,0.9927887,0.00007910009,0.004167837,0.000003967936],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947831,0.0009314358,0.002093838,0.00007435651,0.00001672659,0.00001784717,0.0001569448,0.00003978936,0.00188605],"genre_scores_gemma":[0.9978083,0.0002418954,0.001326624,0.00002609288,0.000004572925,0.00001306178,0.00006357054,0.000004657767,0.0005113698],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008309884,"threshold_uncertainty_score":0.002779901,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03111424959856998,"score_gpt":0.2120861991268752,"score_spread":0.1809719495283052,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}