{"id":"W4256102309","doi":"10.3410/f.737316694.793574115","title":"Faculty Opinions recommendation of Optimizing Nervous System-Specific Gene Targeting with Cre Driver Lines: Prevalence of Germline Recombination and Influencing Factors.","year":2020,"lang":"en","type":"dataset","venue":"Faculty Opinions – Post-Publication Peer Review of the Biomedical Literature","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of Neurological Disorders and Stroke; Japan Society for the Promotion of Science; National Institute of Child Health and Human Development; Natural Sciences and Engineering Research Council of Canada; Eunice Kennedy Shriver National Institute of Child Health and Human Development; University of British Columbia; National Natural Science Foundation of China; National Institute of Mental Health; Fudan University; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; Max-Planck-Gesellschaft; Deutsche Forschungsgemeinschaft; Simons Foundation Autism Research Initiative; Howard Hughes Medical Institute; Ministry of Education, Culture, Sports, Science and Technology; Canadian Institutes of Health Research; National Science Foundation","keywords":"Germline; Recombination; Nervous system; Gene; Genetics; Biology; Computational biology; Neuroscience","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003026569,0.001884402,0.001607725,0.003855126,0.0008165093,0.003388728,0.002717472,0.002183042,0.1200254],"category_scores_gemma":[0.02783699,0.0006824792,0.001793604,0.005566725,0.0003326588,0.001950056,0.002358715,0.001826414,0.1037019],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001826023,"about_ca_system_score_gemma":0.003937711,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.02355787,"about_ca_topic_score_gemma":0.06176234,"domain_scores_codex":[0.9972997,0.0006167311,0.0003564039,0.0006139349,0.0008308659,0.0002823283],"domain_scores_gemma":[0.9858125,0.005782862,0.001647012,0.001642523,0.003874054,0.001241004],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"not_applicable","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000122017,0.00001944921,0.002530048,0.001602987,0.0000879296,0.0000127869,0.00001759093,0.0001789634,0.0001102498,0.0003087557,0.9907003,0.00430898],"study_design_scores_gemma":[0.0004130764,0.00002814525,0.01018814,0.001285427,0.000164105,0.00005592783,0.00007093598,0.0003824945,0.0004611048,0.001019958,0.9858872,0.00004344131],"study_design_candidate":"not_applicable","study_design_consensus":"not_applicable","genre_codex":"dataset","genre_gemma":"dataset","genre_scores_codex":[0.0001033433,0.0001162061,0.00006428803,0.0001500014,0.000031006,0.00001202928,0.9983162,0.0002710665,0.0009359365],"genre_scores_gemma":[0.0006492609,0.0001436663,0.0003904964,0.0002247037,0.00001556267,0.0001023486,0.99694,0.0001460352,0.001387884],"genre_candidate":"dataset","genre_consensus":"dataset","teacher_disagreement_score":0.1200254,"threshold_uncertainty_score":0.4015248,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01579181471023446,"score_gpt":0.3140925013665546,"score_spread":0.2983006866563202,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}