{"id":"W4256116304","doi":"10.21203/rs.3.rs-398836/v1","title":"GSTM1 and GSTT1 Double Null Genotypes Determining Cell Fate and Proliferation as Potential Risk Factors of Relapse in Children with Hematological Malignancies after Stem Cell Transplantation.","year":2021,"lang":"en","type":"preprint","venue":"Research Square","topic":"Glutathione Transferases and Polymorphisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre Hospitalier Universitaire Sainte-Justine","funders":"","keywords":"Transplantation; Null allele; Genotype; Biology; Glutathione; Null cell; Programmed cell death; Oncology; Cancer research; Immunology; Internal medicine; Allele; Medicine; Genetics; Gene; Apoptosis; Enzyme; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000349684,0.0002074396,0.000207866,0.0004809794,0.0001510359,0.0002888523,0.0003251669,0.0003246651,0.001484093],"category_scores_gemma":[0.0011368,0.0001108164,0.0003991796,0.0006549996,0.0001679854,0.0001994488,0.0002599385,0.0004333984,0.0002116677],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002421726,"about_ca_system_score_gemma":0.000347262,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002423184,"about_ca_topic_score_gemma":0.002532399,"domain_scores_codex":[0.9997606,0.00005231946,0.00002094496,0.00006482408,0.00005091091,0.00005036766],"domain_scores_gemma":[0.9991896,0.000170983,0.0004300801,0.00004852637,0.00004758442,0.000113341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0001598823,0.00001397681,0.9972446,0.00001234774,0.00002331936,0.0001300751,0.00003717432,0.0000359572,0.0003578449,0.00002174561,0.0001007717,0.001862304],"study_design_scores_gemma":[0.000005008616,0.0001490956,0.9981635,0.000007780464,0.00004787194,0.000708316,0.00009628325,0.0001842994,0.0002833876,0.00003142703,0.0003207153,0.000002333425],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988301,0.0004105851,0.0000909582,0.00004195891,0.000004401105,0.000004943762,0.0004372158,0.000005372835,0.0001744396],"genre_scores_gemma":[0.9990547,0.0001490144,0.0001170321,0.00001601394,0.000006562099,0.000006465837,0.0004955364,0.000003563341,0.0001510757],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002423184,"threshold_uncertainty_score":0.004964769,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01424814893842681,"score_gpt":0.2686028486184209,"score_spread":0.2543546996799941,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}