{"id":"W4256127173","doi":"10.1093/jnci/djg050","title":"Germline BRCA1 Mutations and a Basal Epithelial Phenotype in Breast Cancer","year":2003,"lang":"en","type":"article","venue":"JNCI Journal of the National Cancer Institute","topic":"Cutaneous Melanoma Detection and Management","field":"Medicine","cited_by":961,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University Health Centre; Jewish General Hospital","funders":"Norges Forskningsråd; Susan G. Komen for the Cure","keywords":"Breast cancer; Cytokeratin; Estrogen receptor; Germline; Phenotype; Germline mutation; Male breast cancer; Cancer research; Biology; Cancer; Internal medicine; Oncology; Pathology; Medicine; Mutation; Immunohistochemistry; Genetics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000255985,0.00008170409,0.0001534846,0.0001680862,0.00008061821,0.00001725825,0.00006564817,0.00003678553,0.0002654653],"category_scores_gemma":[0.0001293627,0.00005618656,0.00007053205,0.0002571209,0.00007299817,0.0001256586,0.0000169685,0.0002222874,0.000002685521],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004147829,"about_ca_system_score_gemma":0.0006039848,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001547311,"about_ca_topic_score_gemma":0.0005264494,"domain_scores_codex":[0.9990332,0.00003417796,0.0002953187,0.00008938924,0.0004461504,0.0001017929],"domain_scores_gemma":[0.9993135,0.00002493243,0.0001843499,0.00005049462,0.0003568934,0.00006983234],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.008591547,0.003541445,0.3941146,0.001027768,0.004032568,0.001263264,0.00559535,0.1316698,0.1570386,0.06805421,0.09565199,0.1294189],"study_design_scores_gemma":[0.008792207,0.0001400049,0.6700727,0.0005888938,0.0003777936,0.004504568,0.0001457846,0.001176305,0.002918121,0.004625801,0.3063458,0.0003120199],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9729787,0.0006268594,0.0001665993,0.01907069,0.00329441,0.0002648713,0.00008361371,0.000008569082,0.003505679],"genre_scores_gemma":[0.9953972,0.0002867252,0.0002965121,0.002321034,0.0006897586,0.00001163318,9.739515e-7,0.000008163118,0.0009880788],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2759582,"threshold_uncertainty_score":0.2906659,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02738752693384942,"score_gpt":0.314240971318956,"score_spread":0.2868534443851065,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}