{"id":"W4256205555","doi":"10.26434/chemrxiv.12510011","title":"Human Neuraminidases Have Reduced Activity Towards Modified Sialic Acids on Glycoproteins","year":2020,"lang":"en","type":"preprint","venue":"ChemRxiv","topic":"Glycosylation and Glycoproteins Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Alberta","funders":"Natural Sciences and Engineering Research Council of Canada; Alberta Glycomics Centre; Universities Space Research Association","keywords":"Glycoprotein; Substrate (aquarium); Enzyme; Sialic acid; Biochemistry; Glycolipid; Chemistry; Mucin; Acetylation; Neuraminidase; Biology; Gene; Ecology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001915723,0.0002495345,0.0001812621,0.0001002137,0.0000602765,0.0001895232,0.0001166811,0.0001514057,0.001409321],"category_scores_gemma":[0.000232248,0.00007986241,0.0001563684,0.0001398091,0.0001549672,0.0001217002,0.000130617,0.0001915633,0.0003346338],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001368696,"about_ca_system_score_gemma":0.00009397548,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001079397,"about_ca_topic_score_gemma":0.0009850496,"domain_scores_codex":[0.9998729,0.00003034331,0.0000104193,0.0000222776,0.00003679407,0.00002719389],"domain_scores_gemma":[0.999918,0.00002203134,0.00001651824,0.00001553581,0.00001471114,0.00001326341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001757083,0.00000805107,0.0008587546,0.00002436523,0.000009978199,0.00007251313,0.0000364163,0.00005532963,0.9961891,0.00008082793,0.00002621705,0.002462779],"study_design_scores_gemma":[0.000004309234,0.0001693296,0.008924739,0.000002184861,0.000009806465,0.0004707519,0.00003920024,0.0002094135,0.9887006,0.00003426565,0.001432257,0.000003164315],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971521,0.0006549456,0.001298741,0.00002090152,0.000005020327,0.000005164792,0.0001413367,0.00002072467,0.000701072],"genre_scores_gemma":[0.9953412,0.0004606129,0.001155279,0.00002103929,0.000003358773,0.000006251533,0.0006291174,0.00001318589,0.002369987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001409321,"threshold_uncertainty_score":0.004714668,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06984655140626159,"score_gpt":0.3427618676910832,"score_spread":0.2729153162848217,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}