{"id":"W4256219020","doi":"10.1002/ange.201203263","title":"Maximizing the Potency of siRNA Lipid Nanoparticles for Hepatic Gene Silencing In Vivo**","year":2012,"lang":"en","type":"article","venue":"Angewandte Chemie","topic":"RNA Interference and Gene Delivery","field":"Biochemistry, Genetics and Molecular Biology","cited_by":152,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia; Encana (Canada)","funders":"","keywords":"Chemistry; In vivo; Gene silencing; Molecular biology; Potency; ED50; Gene; Biochemistry; In vitro; Biology; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006096384,0.0006095762,0.0003873419,0.0002496364,0.0001516201,0.0005245064,0.0002323434,0.0004657695,0.0008709095],"category_scores_gemma":[0.0004608791,0.0001929867,0.0002519063,0.0001611049,0.0002885743,0.0003926198,0.0002575785,0.0003756348,0.00050407],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003767232,"about_ca_system_score_gemma":0.0002692367,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004435968,"about_ca_topic_score_gemma":0.000647484,"domain_scores_codex":[0.9997583,0.00005173822,0.00003212413,0.0000658206,0.00004954814,0.00004235354],"domain_scores_gemma":[0.9997022,0.0001402802,0.00005605654,0.0000310766,0.00004290874,0.00002757244],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005410122,0.00001096694,0.00003330563,0.00002986337,0.00000325963,0.00001083201,0.0000114921,0.0001244908,0.9988457,0.00003275196,0.00001271198,0.0008305883],"study_design_scores_gemma":[0.000003097075,0.0001242081,0.00009889204,0.000001207235,0.000005240916,0.00001059315,0.000002487642,0.0002461562,0.9992436,0.00001143555,0.0002515747,0.000001499494],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9791653,0.002054071,0.01524562,0.0001225114,0.00003076429,0.0001089366,0.0002483171,0.0001941258,0.002830327],"genre_scores_gemma":[0.9897841,0.0009917464,0.006883576,0.00003785084,0.000007984931,0.00008106936,0.000185904,0.00007251903,0.001955197],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0008709095,"threshold_uncertainty_score":0.003224075,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01987565675125786,"score_gpt":0.2503134255758911,"score_spread":0.2304377688246332,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}