{"id":"W4256569365","doi":"10.21203/rs.3.rs-60850/v1","title":"Cell-Free DNA and Circulating Tumor Cell Kinetics in a Pre-Clinical Head and Neck Cancer Model Undergoing Radiation Therapy","year":2020,"lang":"en","type":"preprint","venue":"Research Square (Research Square)","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto; Princess Margaret Cancer Centre","funders":"Princess Margaret Cancer Foundation","keywords":"Liquid biopsy; Medicine; Lymph node; Circulating tumor cell; Head and neck squamous-cell carcinoma; Radiation therapy; Cancer; Head and neck cancer; Cancer research; Primary tumor; Pathology; Cell-free fetal DNA; Oncology; Internal medicine; Biology; Metastasis","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003874674,0.0002570559,0.0004475268,0.0002557181,0.0001363839,0.0003062673,0.0001949999,0.0003516571,0.001065442],"category_scores_gemma":[0.0002485003,0.0001583377,0.0002906891,0.0001577249,0.0003408862,0.0002206053,0.0001896642,0.0006740415,0.0003515597],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003280744,"about_ca_system_score_gemma":0.0002815816,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001217402,"about_ca_topic_score_gemma":0.001677908,"domain_scores_codex":[0.9996949,0.00005148295,0.00002061854,0.00008800242,0.00009024963,0.0000547554],"domain_scores_gemma":[0.9997169,0.00005538183,0.00008206726,0.0000464884,0.00005167129,0.00004728023],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000694187,0.0003971276,0.001492306,0.0000381247,0.0000100019,0.00006873994,0.00009217266,0.0002008285,0.9950801,0.00003418334,0.00005665378,0.001835583],"study_design_scores_gemma":[0.00004331864,0.01694388,0.01525539,0.00000979409,0.00007708043,0.0004200127,0.0001786629,0.003380907,0.9619228,0.00005466984,0.001694753,0.00001869626],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9952719,0.0009390402,0.002803011,0.00003844755,0.00002677031,0.00008552027,0.0002313924,0.00003977021,0.0005642099],"genre_scores_gemma":[0.9934383,0.00058972,0.002472722,0.00003918812,0.00001003883,0.0001400911,0.0005489531,0.00001160043,0.002749346],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001217402,"threshold_uncertainty_score":0.003564239,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.107956230393629,"score_gpt":0.4299620816292476,"score_spread":0.3220058512356185,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}