{"id":"W4256602755","doi":"10.1042/bst0340213","title":"Regulation of protein synthesis by insulin","year":2006,"lang":"en","type":"article","venue":"Biochemical Society Transactions","topic":"PI3K/AKT/mTOR signaling in cancer","field":"Biochemistry, Genetics and Molecular Biology","cited_by":184,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Eukaryotic initiation factor; EIF4E; Cell biology; PI3K/AKT/mTOR pathway; Ribosomal protein s6; Protein kinase B; Phosphorylation; Protein biosynthesis; Biology; Insulin receptor; Initiation factor; Protein kinase A; eIF2; P70-S6 Kinase 1; Biochemistry; Insulin; Translation (biology); Signal transduction; Endocrinology; Insulin resistance","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00007950731,0.0001220381,0.0001181891,0.000009153239,0.0000673331,0.000008094578,0.0001157569,0.0002660085,0.0001092668],"category_scores_gemma":[0.00001491365,0.0001283243,0.0002458491,0.0001245866,0.000143957,0.000003680345,0.000006424387,0.00008672939,0.000003269261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003579016,"about_ca_system_score_gemma":0.0000488843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00008132884,"about_ca_topic_score_gemma":0.000003009159,"domain_scores_codex":[0.999176,0.00002189558,0.0002247432,0.000261856,0.0001492464,0.0001662075],"domain_scores_gemma":[0.9995822,0.00001549805,0.00007445501,0.0002118162,0.00007238551,0.00004363389],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002565733,0.0001276923,0.00002653938,0.00002659904,0.00004476711,2.920448e-8,0.00001243139,0.00006987964,0.9873773,0.00001188762,0.01155859,0.0007186388],"study_design_scores_gemma":[0.0002250923,0.00003930359,0.0001810437,0.00001926745,0.00003177778,0.000001230019,0.00002134979,0.0001014717,0.9863474,0.00007634165,0.01281302,0.0001427043],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9033591,0.001634793,0.09373557,0.0003556217,0.00006070425,0.000230897,0.0002093101,0.00003661354,0.0003774512],"genre_scores_gemma":[0.9946995,0.00004990013,0.004256683,0.00004095184,0.0001323137,0.00005793123,0.0001174349,0.00002087488,0.0006243506],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.09134052,"threshold_uncertainty_score":0.5232912,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004990983504725162,"score_gpt":0.2098323340789857,"score_spread":0.2048413505742606,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}