{"id":"W4256638373","doi":"10.32920/ryerson.14646444.v1","title":"Studies in simultaneous generation of central and axial chirality via the Buchwald-Hartwig reaction","year":2021,"lang":"en","type":"preprint","venue":"","topic":"Axial and Atropisomeric Chirality Synthesis","field":"Chemistry","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Toronto Metropolitan University","funders":"","keywords":"Diastereomer; Axial chirality; Chemistry; Steric effects; Stereochemistry; Enantiomer; Intramolecular force; Ligand (biochemistry); Ring (chemistry); Chirality (physics); Medicinal chemistry; Enantioselective synthesis; Catalysis; Organic chemistry; Physics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001436652,0.0002448725,0.0004642201,0.00001940026,0.00008494598,0.00004121177,0.0001403312,0.0002284154,0.00007943601],"category_scores_gemma":[0.0002489419,0.0001748194,0.0001354136,0.00005519549,0.000228103,0.00005434854,0.0003794051,0.0004145138,6.926456e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001339552,"about_ca_system_score_gemma":0.00005007374,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004285679,"about_ca_topic_score_gemma":0.003147157,"domain_scores_codex":[0.9985501,0.00006674086,0.0005113353,0.000437752,0.0002257233,0.0002083989],"domain_scores_gemma":[0.9989966,0.0002368572,0.000240649,0.0003963556,0.00008878982,0.00004078428],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002583551,0.000824162,0.009363468,0.004696078,0.001266411,0.0001226039,0.01386175,0.007408314,0.8734232,0.002111807,0.0001344012,0.08652942],"study_design_scores_gemma":[0.001556025,0.00007642675,0.01022069,0.001142712,0.0006066256,0.00006403532,0.01080307,0.0537941,0.9113061,0.006798912,0.001762103,0.001869171],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963487,0.0008849077,0.0001496282,0.0006148633,0.0003489729,0.000123842,0.00002392625,0.00003641797,0.001468771],"genre_scores_gemma":[0.9981034,0.0006461866,0.0002220647,0.00008651396,0.0005508585,0.00002140703,0.00007798769,0.00001371952,0.0002778354],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.08466025,"threshold_uncertainty_score":0.7128928,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06207224759689663,"score_gpt":0.2929496770673393,"score_spread":0.2308774294704427,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}