{"id":"W4256643088","doi":"10.1016/j.nmd.2020.08.220","title":"DMD – ANIMAL MODELS & PRECLINICAL TREATMENT","year":2020,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Gene duplication; CRISPR; Cas9; Tandem exon duplication; Guide RNA; Genome editing; Biology; Phenotype; Gene; Genetics; Computational biology; Mutation; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001049622,0.001020131,0.0007488272,0.001079785,0.0006144169,0.0007878645,0.0009571216,0.001771163,0.01517411],"category_scores_gemma":[0.0003557575,0.0002785282,0.0005474211,0.0003792175,0.0009723216,0.0006373021,0.0006572463,0.002289638,0.006773446],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005610965,"about_ca_system_score_gemma":0.0006164091,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004495725,"about_ca_topic_score_gemma":0.0009279727,"domain_scores_codex":[0.9995829,0.00008611659,0.00003724905,0.00006558726,0.0001753534,0.00005270969],"domain_scores_gemma":[0.9997328,0.000044648,0.00005448618,0.00005357729,0.00003843238,0.00007618719],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003491757,0.002806707,0.0009665817,0.003209308,0.0001349101,0.002062439,0.0001391276,0.001690726,0.7813646,0.02018807,0.03784665,0.1460992],"study_design_scores_gemma":[0.0006513225,0.008403626,0.005946812,0.00125363,0.0003668124,0.007636491,0.0001320187,0.00152756,0.4273958,0.008077058,0.538523,0.00008592335],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.3225734,0.1685524,0.1523816,0.02035266,0.006949523,0.006318918,0.02866901,0.007596238,0.2866062],"genre_scores_gemma":[0.4741795,0.1443145,0.09675692,0.006044055,0.001969995,0.006318237,0.02287619,0.0008113162,0.2467292],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01517411,"threshold_uncertainty_score":0.05076247,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03291300773968701,"score_gpt":0.3222993331744531,"score_spread":0.2893863254347661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}