{"id":"W4256643088","doi":"10.1016/j.nmd.2020.08.220","title":"DMD – ANIMAL MODELS & PRECLINICAL TREATMENT","year":2020,"lang":"en","type":"article","venue":"Neuromuscular Disorders","topic":"CRISPR and Genetic Engineering","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":false,"ca_institutions":"Hospital for Sick Children","funders":"","keywords":"Gene duplication; CRISPR; Cas9; Tandem exon duplication; Guide RNA; Genome editing; Biology; Phenotype; Gene; Genetics; Computational biology; Mutation; Bioinformatics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00003414708,0.0001802219,0.0001434192,0.00001466855,0.00004366937,0.0000178125,0.000147872,0.00009665032,0.00002846122],"category_scores_gemma":[0.00005186254,0.000173506,0.0002015148,0.00006984782,0.0000355303,0.000003043351,0.00007165361,0.00007131831,0.00003026868],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005000333,"about_ca_system_score_gemma":0.00002757587,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001066571,"about_ca_topic_score_gemma":0.00003885329,"domain_scores_codex":[0.9990228,0.00003706816,0.0001643154,0.0004363808,0.0001124385,0.0002270223],"domain_scores_gemma":[0.999493,0.000008090123,0.00002462629,0.000297345,0.00001618859,0.000160738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"not_applicable","study_design_scores_codex":[0.000361848,0.0003687534,0.003442774,0.00006471292,0.0002670002,0.000009688546,0.0004861674,0.06634846,0.8944168,0.0001750695,0.00325283,0.03080585],"study_design_scores_gemma":[0.003931016,0.005485732,0.006928177,0.0000117091,0.0001796658,0.00001629074,0.0001126266,0.01783381,0.06378944,0.0002696826,0.9003113,0.001130562],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9584568,0.001624282,0.0361627,0.00162154,0.0001191448,0.0002817331,0.00001350359,0.00005957418,0.001660768],"genre_scores_gemma":[0.9972175,0.0009457694,0.0008061547,0.0005829842,0.0001876545,0.00002463487,0.00007406498,0.0000395298,0.0001217504],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.8970584,"threshold_uncertainty_score":0.7075368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03291300773968701,"score_gpt":0.3222993331744531,"score_spread":0.2893863254347661,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}