{"id":"W4256714406","doi":"10.1093/nass/nrn202","title":"RNA containing pyrrolocytidine base analogs: increased binding affinity and fluorescence that responds to hybridization","year":2008,"lang":"en","type":"article","venue":"Nucleic Acids Symposium Series","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":2,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University; McGill University","funders":"","keywords":"Fluorescence; RNA; DNA; Duplex (building); Chemistry; Base pair; Nucleoside; Substituent; Nucleic acid; Oligonucleotide; Stereochemistry; Biophysics; Biochemistry; Biology; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009838907,0.0002529667,0.000190031,0.00008819966,0.00007669931,0.000150133,0.0001881381,0.0004107775,0.00143513],"category_scores_gemma":[0.0001560209,0.0001439172,0.00008330373,0.00008502636,0.0001289603,0.0001270573,0.00008713188,0.0003210907,0.0004412643],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001397072,"about_ca_system_score_gemma":0.0000643852,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002105477,"about_ca_topic_score_gemma":0.0002921868,"domain_scores_codex":[0.9998877,0.00002008571,0.000004293273,0.00003149065,0.00003392867,0.00002247434],"domain_scores_gemma":[0.9998672,0.00003570528,0.00003624364,0.00001235548,0.00001414628,0.00003429231],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002189361,0.000002832184,0.00002391665,0.000007265721,6.276811e-7,0.00001811166,0.00000337204,0.00001402143,0.9994901,0.00001714094,0.000009346986,0.000391377],"study_design_scores_gemma":[0.000003431613,0.0001158705,0.0009578443,0.000001127283,0.000003126749,0.0002328154,0.000003345333,0.0002097097,0.9977894,0.000008796674,0.0006720192,0.000002468622],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9920601,0.00128656,0.004042813,0.00007234942,0.00002688946,0.0000168651,0.0001186122,0.0001731266,0.002202798],"genre_scores_gemma":[0.9924657,0.0003869894,0.004242493,0.00005171628,0.00001073775,0.00001838971,0.0002953521,0.00002934198,0.002499195],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00143513,"threshold_uncertainty_score":0.004800975,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01273121749216393,"score_gpt":0.2198991964171434,"score_spread":0.2071679789249795,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}