{"id":"W427945141","doi":"10.1016/j.bbagen.2015.05.013","title":"Kinetic characterization of human histone H3 lysine 36 methyltransferases, ASH1L and SETD2","year":2015,"lang":"en","type":"article","venue":"Biochimica et Biophysica Acta (BBA) - General Subjects","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":false,"ca_institutions":"Princess Margaret Cancer Centre; Structural Genomics Consortium; University of Toronto","funders":"Ontario Ministry of Economic Development and Innovation; Ontario Genomics Institute; Janssen Biotech; Medical Engineering Centre King’s College London; Wellcome Trust; Novartis Foundation; GlaxoSmithKline; Takeda Pharmaceuticals U.S.A.; Pfizer","keywords":"Histone methyltransferase; Methyltransferase; Methylation; Histone H3; Chemistry; Histone; Histone methylation; EZH2; Substrate (aquarium); Enzyme; Biochemistry; Biology; DNA methylation; Gene; Gene expression","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003297765,0.0003308314,0.0002939815,0.0002847826,0.0001820718,0.0004212855,0.0004151996,0.0002483189,0.001720773],"category_scores_gemma":[0.000717246,0.0002413945,0.0003150937,0.0004066516,0.0001873214,0.0003602935,0.0001733581,0.0006084119,0.0008048479],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008243706,"about_ca_system_score_gemma":0.0003625407,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002959771,"about_ca_topic_score_gemma":0.002647187,"domain_scores_codex":[0.99983,0.00002006766,0.00001506678,0.00005587695,0.00004680105,0.0000321523],"domain_scores_gemma":[0.999708,0.00009581784,0.00003390608,0.00004546191,0.0000767389,0.00004000213],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001121109,0.00006830267,0.003060344,0.00008002903,0.00005763615,0.00004174574,0.00007448039,0.0008997718,0.9878905,0.0007420116,0.0002651458,0.005698848],"study_design_scores_gemma":[0.00002418313,0.00007768341,0.006686289,0.000003683847,0.00002221699,0.0001040282,0.00003498478,0.006082077,0.9843443,0.0001568741,0.002450562,0.00001310596],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.974515,0.003433935,0.0159604,0.0001871703,0.00005969396,0.00004927733,0.003098721,0.0001257815,0.002570055],"genre_scores_gemma":[0.9814667,0.0008189889,0.005564338,0.0000429036,0.00000983941,0.00004100044,0.005702938,0.00006035485,0.006292936],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002959771,"threshold_uncertainty_score":0.005981326,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02044779510999108,"score_gpt":0.2868531389240418,"score_spread":0.2664053438140507,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}