{"id":"W4280488200","doi":"10.1101/2022.05.17.492122","title":"Structural disruption of BAF chromatin remodeller impairs neuroblastoma metastasis by reverting an invasiveness epigenomic program","year":2022,"lang":"en","type":"preprint","venue":"bioRxiv (Cold Spring Harbor Laboratory)","topic":"Neuroblastoma Research and Treatments","field":"Medicine","cited_by":1,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Instituto de Salud Carlos III; Institució Catalana de Recerca i Estudis Avançats; Ministerio de Economía y Competitividad; Generalitat de Catalunya; Institute for Research in Biomedicine; Centres de Recerca de Catalunya; York University; Ministerio de Ciencia, Innovación y Universidades; “la Caixa” Foundation","keywords":"Epigenomics; Biology; Epigenetics; Chromatin; Cancer research; Neuroblastoma; Cell biology; Chromatin remodeling; Epigenome; Genetics; DNA methylation; Gene expression; Cell culture","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008449098,0.0002445765,0.0001790485,0.0001904233,0.0001183729,0.0001968048,0.0002121572,0.000188868,0.001502335],"category_scores_gemma":[0.00006931028,0.0001184796,0.0002208566,0.00009158242,0.0002146678,0.0001048797,0.0001323172,0.0003706847,0.0003162611],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002753146,"about_ca_system_score_gemma":0.000236749,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001560938,"about_ca_topic_score_gemma":0.002516062,"domain_scores_codex":[0.9999039,0.00001250665,0.00001179021,0.0000213012,0.00002863526,0.00002180298],"domain_scores_gemma":[0.9999157,0.00001299601,0.00002625061,0.00001102546,0.000006864527,0.00002706008],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000513844,0.00001260867,0.0000833423,0.00001148786,0.000003102779,0.00001400966,0.000003760803,0.00002091603,0.9994899,0.00003567493,0.00001119983,0.0002626084],"study_design_scores_gemma":[0.000007252256,0.000140045,0.00442473,0.000003012938,0.00001179672,0.0001015208,0.0000248443,0.0007265888,0.9931648,0.00003042417,0.00136198,0.000002945901],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956905,0.0006989504,0.00210928,0.00006153424,0.00002405436,0.00001972743,0.0005308123,0.00008709589,0.0007778887],"genre_scores_gemma":[0.995602,0.0003960916,0.001153555,0.00002415859,0.000003183055,0.00002546404,0.0005424602,0.00001937997,0.002233593],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001560938,"threshold_uncertainty_score":0.005025804,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02445530088389102,"score_gpt":0.2839909434759438,"score_spread":0.2595356425920528,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}