{"id":"W4280488291","doi":"10.1242/dmm.049544","title":"<i>Snrpb</i> is required in murine neural crest cells for proper splicing and craniofacial morphogenesis","year":2022,"lang":"en","type":"article","venue":"Disease Models & Mechanisms","topic":"RNA Research and Splicing","field":"Biochemistry, Genetics and Molecular Biology","cited_by":21,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; McGill University Health Centre","funders":"Canadian Institutes of Health Research; Azrieli Foundation; McGill University Health Centre","keywords":"Neural crest; Biology; Craniofacial; Exon; Cranial neural crest; Intron; Morphogenesis; Cell biology; RNA splicing; Genetics; Embryo; Gene; RNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002429389,0.0001844667,0.0001724545,0.00007683079,0.0002680536,0.00003960826,0.0002125508,0.00004791463,0.00003610966],"category_scores_gemma":[0.00001913437,0.0001867491,0.0001055751,0.0001011003,0.00003018472,0.0000127846,0.0003429054,0.00009082184,0.000001202978],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002957454,"about_ca_system_score_gemma":0.0001000503,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001136941,"about_ca_topic_score_gemma":0.00001977699,"domain_scores_codex":[0.9984655,0.00007063986,0.0002047202,0.0005490659,0.0002669365,0.0004431308],"domain_scores_gemma":[0.9993376,0.000008927731,0.00004540239,0.0003016311,0.00005032922,0.0002560986],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007559536,0.0001024117,0.0001099848,0.00005291995,0.0000174736,0.00003004072,0.00006392024,0.005770465,0.991245,0.0005418522,0.0003066471,0.001003369],"study_design_scores_gemma":[0.003971501,0.00087683,0.0003754286,0.00002617032,0.00007296274,0.00001516637,0.0003797331,0.4192378,0.5639465,0.008516996,0.001764037,0.0008168815],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9820748,0.0003886625,0.01599082,0.0003388562,0.00008641062,0.0007329456,0.0003404925,0.00001493655,0.00003207498],"genre_scores_gemma":[0.9963186,0.00006443984,0.0008358653,0.001009364,0.0000801576,0.0004885138,0.0001427222,0.0000467845,0.001013569],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4272985,"threshold_uncertainty_score":0.7615408,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0203032048140045,"score_gpt":0.2493875405209024,"score_spread":0.2290843357068979,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}